2b35: Difference between revisions

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[[Image:2b35.gif|left|200px]]


{{Structure
==Crystal structure of Mycobacterium tuberculosis enoyl reductase (InhA) inhibited by triclosan==
|PDB= 2b35 |SIZE=350|CAPTION= <scene name='initialview01'>2b35</scene>, resolution 2.300&Aring;
<StructureSection load='2b35' size='340' side='right'caption='[[2b35]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=TCL:TRICLOSAN'>TCL</scene> and <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>
<table><tr><td colspan='2'>[[2b35]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B35 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B35 FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
|GENE= inhA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=TCL:TRICLOSAN'>TCL</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b35 OCA], [https://pdbe.org/2b35 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b35 RCSB], [https://www.ebi.ac.uk/pdbsum/2b35 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b35 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/INHA_MYCTU INHA_MYCTU]  
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b3/2b35_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b35 ConSurf].
<div style="clear:both"></div>


'''Crystal structure of Mycobacterium tuberculosis enoyl reductase (InhA) inhibited by triclosan'''
==See Also==
 
*[[Enoyl-Acyl-Carrier Protein Reductase 3D structures|Enoyl-Acyl-Carrier Protein Reductase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2B35 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B35 OCA].
[[Category: Large Structures]]
[[Category: Enoyl-[acyl-carrier-protein] reductase (NADH)]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Single protein]]
[[Category: Amin A]]
[[Category: Amin, A.]]
[[Category: Boyne MS]]
[[Category: Boyne, M S.]]
[[Category: Johnson F]]
[[Category: Johnson, F.]]
[[Category: Kaur T]]
[[Category: Kaur, T.]]
[[Category: Novichenok P]]
[[Category: Novichenok, P.]]
[[Category: Stratton C]]
[[Category: Stratton, C.]]
[[Category: Sullivan TJ]]
[[Category: Sullivan, T J.]]
[[Category: Truglio JJ]]
[[Category: Truglio, J J.]]
[[Category: Zhang X]]
[[Category: Zhang, X.]]
[[Category: NAD]]
[[Category: TCL]]
[[Category: enoyl reductase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:56:58 2008''

Latest revision as of 09:15, 14 February 2024

Crystal structure of Mycobacterium tuberculosis enoyl reductase (InhA) inhibited by triclosan

2b35, resolution 2.30Å

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