4c2i: Difference between revisions
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==Cryo-EM structure of Dengue virus serotype 1 complexed with Fab fragments of human antibody 1F4== | ==Cryo-EM structure of Dengue virus serotype 1 complexed with Fab fragments of human antibody 1F4== | ||
< | <SX load='4c2i' size='340' side='right' viewer='molstar' caption='[[4c2i]], [[Resolution|resolution]] 6.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4c2i]] is a 10 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4c2i]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_1 Dengue virus 1] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C2I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C2I FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900017:triacetyl-beta-chitotriose'>PRD_900017</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c2i OCA], [https://pdbe.org/4c2i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c2i RCSB], [https://www.ebi.ac.uk/pdbsum/4c2i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c2i ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/Q7TGE4_9FLAV Q7TGE4_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS027287_004_099774] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4c2i" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[Antibody|Antibody]] | *[[Antibody 3D structures|Antibody 3D structures]] | ||
*[[3D structures of human antibody|3D structures of human antibody]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</ | </SX> | ||
[[Category: Dengue virus 1]] | [[Category: Dengue virus 1]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Crowe Junior JE]] | ||
[[Category: | [[Category: Fibriansah G]] | ||
[[Category: | [[Category: Harris E]] | ||
[[Category: | [[Category: Ibarra KD]] | ||
[[Category: Kostyuchenko | [[Category: Kostyuchenko VA]] | ||
[[Category: Lok | [[Category: Lok S-M]] | ||
[[Category: Ng | [[Category: Ng T-S]] | ||
[[Category: Smith SA]] | |||
[[Category: Smith | [[Category: Tan JL]] | ||
[[Category: Tan | [[Category: De Alwis R]] | ||
[[Category: | [[Category: De Silva A]] | ||
[[Category: | |||
Latest revision as of 11:07, 9 May 2024
Cryo-EM structure of Dengue virus serotype 1 complexed with Fab fragments of human antibody 1F4
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