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[[Image:2b7p.gif|left|200px]]


{{Structure
==Crystal structure of quinolinic acid phosphoribosyltransferase from Helicobacter pylori with phthalic acid==
|PDB= 2b7p |SIZE=350|CAPTION= <scene name='initialview01'>2b7p</scene>, resolution 2.51&Aring;
<StructureSection load='2b7p' size='340' side='right'caption='[[2b7p]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=PHT:PHTHALIC ACID'>PHT</scene>
<table><tr><td colspan='2'>[[2b7p]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B7P FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Nicotinate-nucleotide_diphosphorylase_(carboxylating) Nicotinate-nucleotide diphosphorylase (carboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.19 2.4.2.19]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.51&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PHT:PHTHALIC+ACID'>PHT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b7p OCA], [https://pdbe.org/2b7p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b7p RCSB], [https://www.ebi.ac.uk/pdbsum/2b7p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b7p ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NADC_HELPY NADC_HELPY] Involved in the catabolism of quinolinic acid (QA) (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b7/2b7p_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b7p ConSurf].
<div style="clear:both"></div>


'''Crystal structure of quinolinic acid phosphoribosyltransferase from Helicobacter pylori'''
==See Also==
 
*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2B7P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7P OCA].
 
==Reference==
Crystal structure of quinolinic acid phosphoribosyltransferase from Helicobacter pylori., Kim MK, Im YJ, Lee JH, Eom SH, Proteins. 2006 Apr 1;63(1):252-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16419067 16419067]
[[Category: Helicobacter pylori]]
[[Category: Helicobacter pylori]]
[[Category: Nicotinate-nucleotide diphosphorylase (carboxylating)]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Eom SH]]
[[Category: Eom, S H.]]
[[Category: Im YJ]]
[[Category: Im, Y J.]]
[[Category: Kim MK]]
[[Category: Kim, M K.]]
[[Category: Lee JH]]
[[Category: Lee, J H.]]
[[Category: PHT]]
[[Category: SO4]]
[[Category: helicobacter pylori]]
[[Category: quinolinate phosphoribosyltransferase]]
[[Category: quinolinic acid]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:58:33 2008''

Latest revision as of 09:44, 25 December 2024

Crystal structure of quinolinic acid phosphoribosyltransferase from Helicobacter pylori with phthalic acid

2b7p, resolution 2.51Å

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