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[[Image:2ba2.gif|left|200px]]


{{Structure
==Crystal structure of the DUF16 domain of MPN010 from Mycoplasma pneumoniae==
|PDB= 2ba2 |SIZE=350|CAPTION= <scene name='initialview01'>2ba2</scene>, resolution 1.80&Aring;
<StructureSection load='2ba2' size='340' side='right'caption='[[2ba2]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
|SITE=
== Structural highlights ==
|LIGAND=
<table><tr><td colspan='2'>[[2ba2]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycoplasma_pneumoniae Mycoplasma pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BA2 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
|GENE=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ba2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ba2 OCA], [https://pdbe.org/2ba2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ba2 RCSB], [https://www.ebi.ac.uk/pdbsum/2ba2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ba2 ProSAT], [https://www.topsan.org/Proteins/BSGC/2ba2 TOPSAN]</span></td></tr>
}}
</table>
 
== Function ==
'''Crystal structure of the DUF16 domain of MPN010 from Mycoplasma pneumoniae'''
[https://www.uniprot.org/uniprot/Y010_MYCPN Y010_MYCPN]
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==Overview==
Check<jmol>
We have determined the crystal structure of the DUF16 domain of unknown function encoded by the gene MPN010 of Mycoplasma pneumoniae at 1.8 A resolution. The crystal structure revealed that this domain is composed of two separated homotrimeric coiled-coils. The shorter one consists of 11 highly conserved residues. The sequence comprises noncanonical heptad repeats that induce a right-handed coiled-coil structure. The longer one is composed of approximately nine heptad repeats. In this coiled-coil structure, there are three distinguishable regions that confer unique structural properties compared with other known homotrimeric coiled-coils. The first part, containing one stutter, is an unusual phenylalanine-rich region that is not found in any other coiled-coil structures. The second part is a highly conserved glutamine-rich region, frequently found in other trimeric coiled-coil structures. The last part is composed of prototype heptad repeats. The phylogenetic analysis of the DUF16 family together with a secondary structure prediction shows that the DUF16 family can be classified into five subclasses according to N-terminal sequences. Based on the structural comparison with other coiled-coil structures, a probable molecular function of the DUF16 family is discussed.
  <jmolCheckbox>
 
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ba/2ba2_consurf.spt"</scriptWhenChecked>
==About this Structure==
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
2BA2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycoplasma_pneumoniae Mycoplasma pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BA2 OCA].  
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==Reference==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ba2 ConSurf].
Crystal structure of the DUF16 domain of MPN010 from Mycoplasma pneumoniae., Shin DH, Kim JS, Yokota H, Kim R, Kim SH, Protein Sci. 2006 Apr;15(4):921-8. Epub 2006 Mar 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16522803 16522803]
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycoplasma pneumoniae]]
[[Category: Mycoplasma pneumoniae]]
[[Category: Single protein]]
[[Category: Kim J-S]]
[[Category: BSGC, Berkeley Structural Genomics Center.]]
[[Category: Kim R]]
[[Category: Kim, J S.]]
[[Category: Kim S-H]]
[[Category: Kim, R.]]
[[Category: Shin DH]]
[[Category: Kim, S H.]]
[[Category: Yokota H]]
[[Category: Shin, D H.]]
[[Category: Yokota, H.]]
[[Category: berkeley structural genomics center]]
[[Category: bsgc]]
[[Category: coiled-coil]]
[[Category: duf16]]
[[Category: hypothetical protein]]
[[Category: mpn010]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: structural genomic]]
[[Category: stutter]]
 
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Retrieved from "https://proteopedia.org/2ba2"