4nk7: Difference between revisions

<StructureSection load='4nk7' size='340' side='right'caption='[[4nk7]], [[Resolution|resolution]] 3.23&Aring;' scene=''>

<table><tr><td colspan='2'>[[4nk7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NK7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NK7 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.233&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nk7 OCA], [https://pdbe.org/4nk7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nk7 RCSB], [https://www.ebi.ac.uk/pdbsum/4nk7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nk7 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/PLK4_DROME PLK4_DROME] Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the mother centriole cylinder, using mother centriole as a platform, leading to the recruitment of centriole biogenesis proteins such as Sas-6. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Centrosome amplification following overexpression can initiate tumorigenesis, highlighting the importance of centrosome regulation in cancers.<ref>PMID:16326102</ref> <ref>PMID:17463247</ref> <ref>PMID:18555779</ref>  

[[Category: Drosophila melanogaster]]

[[Category: Large Structures]]

[[Category: Dong G]]

[[Category: Lesigang J]]