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==High resolution structure of E.coli WrbA with FMN==
==High resolution structure of E.coli WrbA with FMN==
<StructureSection load='4dy4' size='340' side='right' caption='[[4dy4]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
<StructureSection load='4dy4' size='340' side='right'caption='[[4dy4]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4dy4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_apec_o1 Escherichia coli apec o1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DY4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DY4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4dy4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_APEC_O1 Escherichia coli APEC O1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DY4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DY4 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">wrbA, Ecok1_09050, APECO1_95 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=405955 Escherichia coli APEC O1])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dy4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dy4 RCSB], [http://www.ebi.ac.uk/pdbsum/4dy4 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dy4 OCA], [https://pdbe.org/4dy4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dy4 RCSB], [https://www.ebi.ac.uk/pdbsum/4dy4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dy4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/WRBA_ECOK1 WRBA_ECOK1]] It seems to function in response to environmental stress when various electron transfer chains are affected or when the environment is highly oxidizing. It reduces quinones to the hydroquinone state to prevent interaction of the semiquinone with O2 and production of superoxide (By similarity).
[https://www.uniprot.org/uniprot/E2QJP6_ECOLX E2QJP6_ECOLX]  
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Escherichia coli apec o1]]
[[Category: Escherichia coli APEC O1]]
[[Category: Brynda, J]]
[[Category: Large Structures]]
[[Category: Carey, J]]
[[Category: Brynda J]]
[[Category: Ettrich, R]]
[[Category: Carey J]]
[[Category: Kishko, I]]
[[Category: Ettrich R]]
[[Category: Smatanova, I Kuta]]
[[Category: Kishko I]]
[[Category: Nadh oxidoreductase]]
[[Category: Kuta Smatanova I]]
[[Category: Rossmann fold]]
[[Category: Transcription]]

Latest revision as of 11:00, 1 March 2024

High resolution structure of E.coli WrbA with FMN

4dy4, resolution 1.20Å

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