2bpa: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
 
(13 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:2bpa.gif|left|200px]]


{{Structure
==ATOMIC STRUCTURE OF SINGLE-STRANDED DNA BACTERIOPHAGE PHIX174 AND ITS FUNCTIONAL IMPLICATIONS==
|PDB= 2bpa |SIZE=350|CAPTION= <scene name='initialview01'>2bpa</scene>, resolution 3.000&Aring;
<StructureSection load='2bpa' size='340' side='right'caption='[[2bpa]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
|SITE=
== Structural highlights ==
|LIGAND=
<table><tr><td colspan='2'>[[2bpa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_phiX174 Escherichia virus phiX174]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BPA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BPA FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
|GENE=  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bpa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bpa OCA], [https://pdbe.org/2bpa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bpa RCSB], [https://www.ebi.ac.uk/pdbsum/2bpa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bpa ProSAT]</span></td></tr>
}}
</table>
 
== Function ==
'''ATOMIC STRUCTURE OF SINGLE-STRANDED DNA BACTERIOPHAGE PHIX174 AND ITS FUNCTIONAL IMPLICATIONS'''
[https://www.uniprot.org/uniprot/CAPSD_BPPHS CAPSD_BPPHS] Assembles to form an icosahedral capsid with a T=1 symmetry, about 30 nm in diameter, and consisting of 60 capsid proteins F (PubMed:11991963, PubMed:1370343, PubMed:8158636). Upon virus binding to host cell, one of the spikes dissociates from the capsid and the virus interacts with LPS through the exposed EF loops on the F proteins (PubMed:29229840). After the genome had been ejected, the channel formed by the F proteins at the unique fivefold axis remains open (PubMed:29229840).<ref>PMID:11991963</ref> <ref>PMID:1370343</ref> <ref>PMID:29229840</ref> <ref>PMID:8158636</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==Overview==
Check<jmol>
The mechanism of DNA ejection, viral assembly and evolution are related to the structure of bacteriophage phi X174. The F protein forms a T = 1 capsid whose major folding motif is the eight-stranded antiparallel beta barrel found in many other icosahedral viruses. Groups of 5 G proteins form 12 dominating spikes that enclose a hydrophilic channel containing some diffuse electron density. Each G protein is a tight beta barrel with its strands running radially outwards and with a topology similar to that of the F protein. The 12 'pilot' H proteins per virion may be partially located in the putative ion channel. The small, basic J protein is associated with the DNA and is situated in an interior cleft of the F protein. Tentatively, there are three regions of partially ordered DNA structure,
  <jmolCheckbox>
 
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bp/2bpa_consurf.spt"</scriptWhenChecked>
==About this Structure==
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
2BPA is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Enterobacteria_phage_phix174 Enterobacteria phage phix174]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BPA OCA].  
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==Reference==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bpa ConSurf].
Atomic structure of single-stranded DNA bacteriophage phi X174 and its functional implications., McKenna R, Xia D, Willingmann P, Ilag LL, Krishnaswamy S, Rossmann MG, Olson NH, Baker TS, Incardona NL, Nature. 1992 Jan 9;355(6356):137-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1370343 1370343]
<div style="clear:both"></div>
[[Category: Enterobacteria phage phix174]]
== References ==
[[Category: Protein complex]]
<references/>
[[Category: Baker, T S.]]
__TOC__
[[Category: Ilag, L L.]]
</StructureSection>
[[Category: Incardona, N L.]]
[[Category: Escherichia virus phiX174]]
[[Category: Krishnaswamy, S.]]
[[Category: Large Structures]]
[[Category: McKenna, R.]]
[[Category: Baker TS]]
[[Category: Olson, N H.]]
[[Category: Ilag LL]]
[[Category: Rossmann, M G.]]
[[Category: Incardona NL]]
[[Category: Willingmann, P.]]
[[Category: Krishnaswamy S]]
[[Category: Xia, D.]]
[[Category: McKenna R]]
[[Category: icosahedral virus]]
[[Category: Olson NH]]
[[Category: protein-dna complex]]
[[Category: Rossmann MG]]
[[Category: single strand]]
[[Category: Willingmann P]]
 
[[Category: Xia D]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:04:56 2008''

Latest revision as of 09:17, 14 February 2024

ATOMIC STRUCTURE OF SINGLE-STRANDED DNA BACTERIOPHAGE PHIX174 AND ITS FUNCTIONAL IMPLICATIONS

2bpa, resolution 3.00Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=2bpa&oldid=4058022"