2c0z: Difference between revisions

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[[Image:2c0z.gif|left|200px]]


{{Structure
==The 1.6 A resolution crystal structure of NovW: a 4-keto-6-deoxy sugar epimerase from the novobiocin biosynthetic gene cluster of Streptomyces spheroides==
|PDB= 2c0z |SIZE=350|CAPTION= <scene name='initialview01'>2c0z</scene>, resolution 1.60&Aring;
<StructureSection load='2c0z' size='340' side='right'caption='[[2c0z]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
|SITE= <scene name='pdbsite=AC1:Edo+Binding+Site+For+Chain+A'>AC1</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>
<table><tr><td colspan='2'>[[2c0z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_niveus_NCIMB_11891 Streptomyces niveus NCIMB 11891]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C0Z FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c0z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0z OCA], [https://pdbe.org/2c0z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c0z RCSB], [https://www.ebi.ac.uk/pdbsum/2c0z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c0z ProSAT]</span></td></tr>
 
</table>
'''THE 1.6 A RESOLUTION CRYSTAL STRUCTURE OF NOVW: A 4-KETO-6-DEOXY SUGAR EPIMERASE FROM THE NOVOBIOCIN BIOSYNTHETIC GENE CLUSTER OF STREPTOMYCES SPHEROIDES'''
== Function ==
 
[https://www.uniprot.org/uniprot/NOVW_STRNV NOVW_STRNV] dTDP-6-deoxy-D-xylo-4-hexulose 3-epimerase that acts together with NovU to catalyze the formation of dTDP-4-keto-6-deoxy-5-C-methyl-L-lyxo-hexose from dTDP-4-keto-6-deoxy-D-glucose in the novobiocin biosynthesis pathway, an aminocoumarin family antibiotic that targets bacterial DNA gyrases.<ref>PMID:15752721</ref> <ref>PMID:16514445</ref>
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
2C0Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_caeruleus Streptomyces caeruleus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0Z OCA].
Check<jmol>
[[Category: Single protein]]
  <jmolCheckbox>
[[Category: Streptomyces caeruleus]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c0/2c0z_consurf.spt"</scriptWhenChecked>
[[Category: Buttner, M J.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Field, R A.]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Freel-Meyers, C L.]]
  </jmolCheckbox>
[[Category: Jakimowicz, P.]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c0z ConSurf].
[[Category: Lawson, D M.]]
<div style="clear:both"></div>
[[Category: Tello, M.]]
== References ==
[[Category: Walsh, C T.]]
<references/>
[[Category: EDO]]
__TOC__
[[Category: SO4]]
</StructureSection>
[[Category: antibiotic biosynthesis]]
[[Category: Large Structures]]
[[Category: epimerase]]
[[Category: Streptomyces niveus NCIMB 11891]]
[[Category: isomerase]]
[[Category: Buttner MJ]]
[[Category: rmlc-like cupin]]
[[Category: Field RA]]
 
[[Category: Freel-Meyers CL]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:09:21 2008''
[[Category: Jakimowicz P]]
[[Category: Lawson DM]]
[[Category: Tello M]]
[[Category: Walsh CT]]
Retrieved from "https://proteopedia.org/2c0z"