4lrr: Difference between revisions
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==Ternary complex between E. coli thymidylate synthase, dUMP, and F9== | ==Ternary complex between E. coli thymidylate synthase, dUMP, and F9== | ||
<StructureSection load='4lrr' size='340' side='right' caption='[[4lrr]], [[Resolution|resolution]] 2.41Å' scene=''> | <StructureSection load='4lrr' size='340' side='right'caption='[[4lrr]], [[Resolution|resolution]] 2.41Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4lrr]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4lrr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LRR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LRR FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.41Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CF9:2-OXO-2H-NAPHTHO[1,8-BC]FURAN-6-YL+4-NITROBENZOATE'>CF9</scene>, <scene name='pdbligand=SCH:S-METHYL-THIO-CYSTEINE'>SCH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lrr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lrr OCA], [https://pdbe.org/4lrr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lrr RCSB], [https://www.ebi.ac.uk/pdbsum/4lrr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lrr ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/TYSY_ECO57 TYSY_ECO57] Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4lrr" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[Thymidylate synthase|Thymidylate synthase]] | *[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Escherichia coli O157:H7]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Costi | [[Category: Costi MP]] | ||
[[Category: Ferrari | [[Category: Ferrari S]] | ||
[[Category: Mangani | [[Category: Mangani S]] | ||
[[Category: Pozzi | [[Category: Pozzi C]] | ||
Latest revision as of 23:02, 26 March 2025
Ternary complex between E. coli thymidylate synthase, dUMP, and F9
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