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==Night blindness causing G90D rhodopsin in the active conformation==
==Night blindness causing G90D rhodopsin in the active conformation==
<StructureSection load='4bez' size='340' side='right' caption='[[4bez]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
<StructureSection load='4bez' size='340' side='right'caption='[[4bez]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4bez]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BEZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BEZ FirstGlance]. <br>
<table><tr><td colspan='2'>[[4bez]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BEZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BEZ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bey|4bey]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bez OCA], [https://pdbe.org/4bez PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bez RCSB], [https://www.ebi.ac.uk/pdbsum/4bez PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bez ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bez OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bez RCSB], [http://www.ebi.ac.uk/pdbsum/4bez PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN]] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref>
[https://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4bez" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Rhodopsin|Rhodopsin]]
*[[Rhodopsin 3D structures|Rhodopsin 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Deupi, X]]
[[Category: Large Structures]]
[[Category: Gurevich, V V]]
[[Category: Deupi X]]
[[Category: Homan, K T]]
[[Category: Gurevich VV]]
[[Category: Ostermaier, M K]]
[[Category: Homan KT]]
[[Category: Panneels, V]]
[[Category: Ostermaier MK]]
[[Category: Schertler, G F.X]]
[[Category: Panneels V]]
[[Category: Singhal, A]]
[[Category: Schertler GFX]]
[[Category: Standfuss, J]]
[[Category: Singhal A]]
[[Category: Tesmer, J J.G]]
[[Category: Standfuss J]]
[[Category: Veprintsev, D]]
[[Category: Tesmer JJG]]
[[Category: Vishnivetskiy, S A]]
[[Category: Veprintsev D]]
[[Category: Active state]]
[[Category: Vishnivetskiy SA]]
[[Category: Congential stationary night blindness]]
[[Category: Disease mutant]]
[[Category: Gpcr]]
[[Category: Membrane protein]]

Latest revision as of 11:49, 20 December 2023

Night blindness causing G90D rhodopsin in the active conformation

4bez, resolution 3.30Å

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