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[[Image:2cff.jpg|left|200px]]
==CRYSTAL STRUCTURE OF N-((5'-PHOSPHORIBOSYL)-FORMIMINO)-5-AMINOIMIDAZOL-4-CARBOXAMID RIBONUCLEOTID ISOMERASE MUTANT D127V (EC 3.1.3.15, HISA)==
 
<StructureSection load='2cff' size='340' side='right' caption='[[2cff]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
{{Structure
== Structural highlights ==
|PDB= 2cff |SIZE=350|CAPTION= <scene name='initialview01'>2cff</scene>, resolution 2.500&Aring;
<table><tr><td colspan='2'>[[2cff]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CFF FirstGlance]. <br>
|SITE= <scene name='pdbsite=AC1:Mpd+Binding+Site+For+Chain+A'>AC1</scene>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
|LIGAND= <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1qo2|1qo2]]</td></tr>
|ACTIVITY= [http://en.wikipedia.org/wiki/1-(5-phosphoribosyl)-5-_((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide_isomerase 1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.16 5.3.1.16]  
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-(5-phosphoribosyl)-5-_((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide_isomerase 1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.16 5.3.1.16] </span></td></tr>
|GENE=  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cff OCA], [http://pdbe.org/2cff PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cff RCSB], [http://www.ebi.ac.uk/pdbsum/2cff PDBsum]</span></td></tr>
}}
</table>
 
== Evolutionary Conservation ==
'''CRYSTAL STRUCTURE OF N-((5'-PHOSPHORIBOSYL)-FORMIMINO)-5-AMINOIMIDAZOL-4-CARBOXAMID RIBONUCLEOTID ISOMERASE MUTANT D127V (EC 3.1.3.15, HISA)'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cf/2cff_consurf.spt"</scriptWhenChecked>
2CFF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFF OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: 1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Single protein]]
  </jmolCheckbox>
[[Category: Thermotoga maritima]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cff ConSurf].
[[Category: He, C.]]
<div style="clear:both"></div>
[[Category: Kuper, J.]]
__TOC__
[[Category: Sterner, R.]]
</StructureSection>
[[Category: Wilmmans, M.]]
[[Category: Atcc 43589]]
[[Category: MPD]]
[[Category: He, C]]
[[Category: amino-acid biosynthesis]]
[[Category: Kuper, J]]
[[Category: histidine biosynthesis]]
[[Category: Sterner, R]]
[[Category: isomerase]]
[[Category: Wilmmans, M]]
[[Category: thermophilic protein]]
[[Category: Amino-acid biosynthesis]]
 
[[Category: Histidine biosynthesis]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:14:45 2008''
[[Category: Isomerase]]
[[Category: Thermophilic protein]]

Latest revision as of 05:36, 7 February 2016

CRYSTAL STRUCTURE OF N-((5'-PHOSPHORIBOSYL)-FORMIMINO)-5-AMINOIMIDAZOL-4-CARBOXAMID RIBONUCLEOTID ISOMERASE MUTANT D127V (EC 3.1.3.15, HISA)

2cff, resolution 2.50Å

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