2cl8: Difference between revisions

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[[Image:2cl8.jpg|left|200px]]


{{Structure
==Dectin-1 in complex with beta-glucan==
|PDB= 2cl8 |SIZE=350|CAPTION= <scene name='initialview01'>2cl8</scene>, resolution 2.80&Aring;
<StructureSection load='2cl8' size='340' side='right'caption='[[2cl8]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
|SITE= <scene name='pdbsite=AC1:Bgc+Binding+Site+For+Chain+A'>AC1</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=CL:CHLORIDE ION'>CL</scene>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CL8 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cl8 OCA], [https://pdbe.org/2cl8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cl8 RCSB], [https://www.ebi.ac.uk/pdbsum/2cl8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cl8 ProSAT]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cl/2cl8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cl8 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The murine molecule dectin-1 (known as the beta-glucan receptor in humans) is an immune cell surface receptor implicated in the immunological defense against fungal pathogens. Sequence analysis has indicated that the dectin-1 extracellular domain is a C-type lectin-like domain, and functional studies have established that it binds fungal beta-glucans. We report several dectin-1 crystal structures, including a high-resolution structure and a 2.8 angstroms resolution structure in which a short soaked natural beta-glucan is trapped in the crystal lattice. In vitro characterization of dectin-1 in the presence of its natural ligand indicates higher-order complex formation between dectin-1 and beta-glucans. These combined structural and biophysical data considerably extend the current knowledge of dectin-1 structure and function, and suggest potential mechanisms of defense against fungal pathogens.


'''DECTIN-1 IN COMPLEX WITH BETA-GLUCAN'''
Structure of the fungal beta-glucan-binding immune receptor dectin-1: implications for function.,Brown J, O'Callaghan CA, Marshall AS, Gilbert RJ, Siebold C, Gordon S, Brown GD, Jones EY Protein Sci. 2007 Jun;16(6):1042-52. Epub 2007 May 1. PMID:17473009<ref>PMID:17473009</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
==About this Structure==
</div>
2CL8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CL8 OCA].
<div class="pdbe-citations 2cl8" style="background-color:#fffaf0;"></div>
[[Category: Mus musculus]]
== References ==
[[Category: Single protein]]
<references/>
[[Category: Brown, G D.]]
__TOC__
[[Category: Brown, J.]]
</StructureSection>
[[Category: Callaghan, C A.O.]]
[[Category: Large Structures]]
[[Category: Gilbert, R J.C.]]
[[Category: Brown GD]]
[[Category: Gordon, S.]]
[[Category: Brown J]]
[[Category: Jones, E Y.]]
[[Category: Gilbert RJC]]
[[Category: Marshall, A S.J.]]
[[Category: Gordon S]]
[[Category: Siebold, C.]]
[[Category: Jones EY]]
[[Category: CA]]
[[Category: Marshall ASJ]]
[[Category: CL]]
[[Category: O'Callaghan CA]]
[[Category: beta-glucan]]
[[Category: Siebold C]]
[[Category: c-type lectin-like domain]]
[[Category: carbohydrate]]
[[Category: ctld]]
[[Category: dectin-1]]
[[Category: fungal recognition]]
[[Category: laminarin]]
[[Category: receptor]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:16:50 2008''

Latest revision as of 09:03, 6 November 2024

Dectin-1 in complex with beta-glucan

2cl8, resolution 2.80Å

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