2cy6: Difference between revisions

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[[Image:2cy6.gif|left|200px]]


{{Structure
==Crystal structure of ConM in complex with trehalose and maltose==
|PDB= 2cy6 |SIZE=350|CAPTION= <scene name='initialview01'>2cy6</scene>, resolution 2.00&Aring;
<StructureSection load='2cy6' size='340' side='right'caption='[[2cy6]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene> and <scene name='pdbligand=TRE:TREHALOSE'>TRE</scene>
<table><tr><td colspan='2'>[[2cy6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_rosea Canavalia rosea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CY6 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PRD_900006:trehalose'>PRD_900006</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cy6 OCA], [https://pdbe.org/2cy6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cy6 RCSB], [https://www.ebi.ac.uk/pdbsum/2cy6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cy6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CONA_CANLI CONA_CANLI] Glucose/D-mannose specific lectin.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cy/2cy6_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cy6 ConSurf].
<div style="clear:both"></div>


'''Crystal structure of ConM in complex with trehalose and maltose'''
==See Also==
 
*[[Concanavalin 3D structures|Concanavalin 3D structures]]
 
__TOC__
==Overview==
</StructureSection>
The crystal structure of Canavalia maritima lectin (ConM) complexed with trehalose and maltose revealed relevant point mutations in ConA-like lectins. ConM with the disaccharides and other ConA-like lectins complexed with carbohydrates demonstrated significant differences in the position of H-bonds. The main difference in the ConM structure is the replacement of Pro202 by Ser202, a residue that promotes the approximation of Tyr12 to the carbohydrate-binding site. The O-6' of the second glucose ring in maltose interacts with Tyr12, while in trehalose the interaction is established by the O-2' and Tyr12, explaining the higher affinity of ConM for disaccharides compared to monosaccharides.
[[Category: Canavalia rosea]]
 
[[Category: Large Structures]]
==About this Structure==
[[Category: Azevedo Jr WF]]
2CY6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Canavalia_maritima Canavalia maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CY6 OCA].
[[Category: Cavada BS]]
 
[[Category: Delatorre P]]
==Reference==
[[Category: Gadelha CAA]]
Crystal structure of a lectin from Canavalia maritima (ConM) in complex with trehalose and maltose reveals relevant mutation in ConA-like lectins., Delatorre P, Rocha BA, Gadelha CA, Santi-Gadelha T, Cajazeiras JB, Souza EP, Nascimento KS, Freire VN, Sampaio AH, Azevedo WF Jr, Cavada BS, J Struct Biol. 2006 Jun;154(3):280-6. Epub 2006 Apr 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16677825 16677825]
[[Category: Rocha BAM]]
[[Category: Canavalia maritima]]
[[Category: Souza EP]]
[[Category: Protein complex]]
[[Category: Cavada, B S.]]
[[Category: Delatorre, P.]]
[[Category: Gadelha, C A.A.]]
[[Category: Jr., W F.Azevedo.]]
[[Category: Rocha, B A.M.]]
[[Category: Souza, E P.]]
[[Category: CA]]
[[Category: MN]]
[[Category: TRE]]
[[Category: canavalia maritima]]
[[Category: lectin]]
[[Category: trehalose]]
[[Category: x-ray diffraction]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:21:09 2008''
Retrieved from "https://proteopedia.org/2cy6"