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==Crystal Structure of Mammalian Period-Cryptochrome Complex==
==Crystal Structure of Mammalian Period-Cryptochrome Complex==
<StructureSection load='4u8h' size='340' side='right' caption='[[4u8h]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='4u8h' size='340' side='right'caption='[[4u8h]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4u8h]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U8H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U8H FirstGlance]. <br>
<table><tr><td colspan='2'>[[4u8h]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U8H FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.798&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u8h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u8h RCSB], [http://www.ebi.ac.uk/pdbsum/4u8h PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u8h OCA], [https://pdbe.org/4u8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u8h RCSB], [https://www.ebi.ac.uk/pdbsum/4u8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u8h ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PER2_MOUSE PER2_MOUSE]] Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK|NPAS2-BMAL1|BMAL2-induced transactivation.<ref>PMID:10428031</ref> <ref>PMID:17310242</ref> 
[https://www.uniprot.org/uniprot/CRY2_MOUSE CRY2_MOUSE]  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4u8h" style="background-color:#fffaf0;"></div>
==See Also==
*[[Cryptochrome 3D structures|Cryptochrome 3D structures]]
*[[Period circadian protein|Period circadian protein]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Green, C B]]
[[Category: Large Structures]]
[[Category: Koike, N]]
[[Category: Mus musculus]]
[[Category: Nangle, S N]]
[[Category: Green CB]]
[[Category: Rosensweig, C]]
[[Category: Koike N]]
[[Category: Takahashi, J S]]
[[Category: Nangle SN]]
[[Category: Tei, H]]
[[Category: Rosensweig C]]
[[Category: Zheng, N]]
[[Category: Takahashi JS]]
[[Category: Circadian clock protein-transcription complex]]
[[Category: Tei H]]
[[Category: Transcriptional repression]]
[[Category: Zheng N]]
[[Category: Zinc-binding]]
Retrieved from "https://proteopedia.org/4u8h"