2deb: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(15 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:2deb.jpg|left|200px]]


{{Structure
==Crystal structure of rat carnitine palmitoyltransferase 2 in space group C2221==
|PDB= 2deb |SIZE=350|CAPTION= <scene name='initialview01'>2deb</scene>, resolution 1.60&Aring;
<StructureSection load='2deb' size='340' side='right'caption='[[2deb]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene> and <scene name='pdbligand=PLM:PALMITIC ACID'>PLM</scene>
<table><tr><td colspan='2'>[[2deb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DEB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DEB FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Carnitine_O-palmitoyltransferase Carnitine O-palmitoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.21 2.3.1.21]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2deb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2deb OCA], [https://pdbe.org/2deb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2deb RCSB], [https://www.ebi.ac.uk/pdbsum/2deb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2deb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CPT2_RAT CPT2_RAT]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/de/2deb_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2deb ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Carnitine palmitoyltransferases (CPTs) are part of the enzymatic system that imports fatty acids into mitochondria. The crystal structure of rat CPT-2 by Rufer et al. (2006) (this issue of Structure) reveals a Y-shaped tunnel for binding the CoA and acyl-carnitine substrates and a hydrophobic insert mediating membrane association.


'''Crystal structure of rat carnitine palmitoyltransferase 2 in space group C2221'''
A monotopic membrane protein goes solo.,Mattevi A Structure. 2006 Apr;14(4):628-9. PMID:16615901<ref>PMID:16615901</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2deb" style="background-color:#fffaf0;"></div>


==Overview==
==See Also==
Carnitine palmitoyltransferases (CPTs) are part of the enzymatic system that imports fatty acids into mitochondria. The crystal structure of rat CPT-2 by Rufer et al. (2006) (this issue of Structure) reveals a Y-shaped tunnel for binding the CoA and acyl-carnitine substrates and a hydrophobic insert mediating membrane association.
*[[Carnitine palmitoyltransferase|Carnitine palmitoyltransferase]]
 
== References ==
==About this Structure==
<references/>
2DEB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DEB OCA].
__TOC__
 
</StructureSection>
==Reference==
[[Category: Large Structures]]
A monotopic membrane protein goes solo., Mattevi A, Structure. 2006 Apr;14(4):628-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16615901 16615901]
[[Category: Carnitine O-palmitoyltransferase]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Single protein]]
[[Category: Banner DW]]
[[Category: Banner, D W.]]
[[Category: Benz J]]
[[Category: Benz, J.]]
[[Category: Chomienne O]]
[[Category: Chomienne, O.]]
[[Category: De Roo E]]
[[Category: Gsell, B.]]
[[Category: Gsell B]]
[[Category: Hennig, M.]]
[[Category: Hennig M]]
[[Category: Mueller, F.]]
[[Category: Mueller F]]
[[Category: Roo, E De.]]
[[Category: Rufer AC]]
[[Category: Rufer, A C.]]
[[Category: Stihle M]]
[[Category: Stihle, M.]]
[[Category: Thoma R]]
[[Category: Thoma, R.]]
[[Category: BOG]]
[[Category: COA]]
[[Category: PLM]]
[[Category: central six-stranded beta-sheet]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:26:13 2008''

Latest revision as of 07:55, 30 October 2024

Crystal structure of rat carnitine palmitoyltransferase 2 in space group C2221

2deb, resolution 1.60Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=2deb&oldid=4245863"