4a5x: Difference between revisions

<StructureSection load='4a5x' size='340' side='right' caption='[[4a5x]], [[Resolution|resolution]] 1.91&Aring;' scene=''>

<table><tr><td colspan='2'>[[4a5x]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A5X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A5X FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=P15:2,5,8,11,14,17-HEXAOXANONADECAN-19-OL'>P15</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a5x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a5x RCSB], [http://www.ebi.ac.uk/pdbsum/4a5x PDBsum]</span></td></tr>

[[http://www.uniprot.org/uniprot/MITD1_HUMAN MITD1_HUMAN]] Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex.<ref>PMID:23015756</ref> <ref>PMID:23045692</ref> [[http://www.uniprot.org/uniprot/CHM1A_HUMAN CHM1A_HUMAN]] Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.<ref>PMID:8863740</ref> <ref>PMID:11559747</ref> <ref>PMID:11559748</ref> <ref>PMID:19129479</ref> <ref>PMID:23045692</ref> 

[[Category: Human]]

[[Category: Agromayor, M]]

[[Category: Caballe, A]]

[[Category: Hadders, M A]]

[[Category: Martin-Serrano, J]]

[[Category: Obita, T]]

[[Category: Perisic, O]]

[[Category: Williams, R L]]

[[Category: Protein transport]]