2dkx: Difference between revisions

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[[Image:2dkx.gif|left|200px]]


{{Structure
==Solution structure of the SAM_PNT-domain of ETS transcription factor PDEF (Prostate ets)==
|PDB= 2dkx |SIZE=350|CAPTION= <scene name='initialview01'>2dkx</scene>
<StructureSection load='2dkx' size='340' side='right'caption='[[2dkx]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[2dkx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DKX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DKX FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
|GENE= SPDEF, PDEF, PSE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dkx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dkx OCA], [https://pdbe.org/2dkx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dkx RCSB], [https://www.ebi.ac.uk/pdbsum/2dkx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dkx ProSAT], [https://www.topsan.org/Proteins/RSGI/2dkx TOPSAN]</span></td></tr>
}}
</table>
 
== Function ==
'''Solution structure of the SAM_PNT-domain of ETS transcription factor PDEF (Prostate ets)'''
[https://www.uniprot.org/uniprot/SPDEF_HUMAN SPDEF_HUMAN] May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter.<ref>PMID:10625666</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==Disease==
Check<jmol>
Known diseases associated with this structure: Alzheimer disease, type 3 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=104311 104311]], Alzheimer disease, type 3, with spastic paraparesis and apraxia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=104311 104311]], Alzheimer disease, type 3, with spastic paraparesis and unusual plaques OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=104311 104311]], Cardiomyopathy, dilated, 1U OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=104311 104311]], Dementia, frontotemporal OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=104311 104311]], Pick disease OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=104311 104311]]
  <jmolCheckbox>
 
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dk/2dkx_consurf.spt"</scriptWhenChecked>
==About this Structure==
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
2DKX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DKX OCA].  
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dkx ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Goroncy, A K.]]
[[Category: Goroncy AK]]
[[Category: Inoue, M.]]
[[Category: Inoue M]]
[[Category: Kigawa, T.]]
[[Category: Kigawa T]]
[[Category: Koshiba, S.]]
[[Category: Koshiba S]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Sato M]]
[[Category: Sato, M.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: cell-free protein synthesis]]
[[Category: national project on protein structural and functional analyse]]
[[Category: nppsfa]]
[[Category: protein regulation]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:28:23 2008''

Latest revision as of 18:43, 29 May 2024

Solution structure of the SAM_PNT-domain of ETS transcription factor PDEF (Prostate ets)

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