2dls: Difference between revisions

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[[Image:2dls.jpg|left|200px]]


{{Structure
==Solution structure of the PDZ domain of human Rho guanine nucleotide exchange factor 11==
|PDB= 2dls |SIZE=350|CAPTION= <scene name='initialview01'>2dls</scene>
<StructureSection load='2dls' size='340' side='right'caption='[[2dls]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[2dls]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DLS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DLS FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
|GENE= ARHGEF11, KIAA0380 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dls OCA], [https://pdbe.org/2dls PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dls RCSB], [https://www.ebi.ac.uk/pdbsum/2dls PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dls ProSAT], [https://www.topsan.org/Proteins/RSGI/2dls TOPSAN]</span></td></tr>
}}
</table>
== Function ==
[https://www.uniprot.org/uniprot/ARHGB_HUMAN ARHGB_HUMAN] May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dl/2dls_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dls ConSurf].
<div style="clear:both"></div>


'''Solution structure of the PDZ domain of human Rho guanine nucleotide exchange factor 11'''
==See Also==
 
*[[Rho guanine nucleotide exchange factor 3D structures|Rho guanine nucleotide exchange factor 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2DLS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DLS OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Hayashi, F.]]
[[Category: Hayashi F]]
[[Category: Inoue, K.]]
[[Category: Inoue K]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Suetake T]]
[[Category: Suetake, T.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: arhgef11]]
[[Category: kiaa0380]]
[[Category: national project on protein structural and functional analyse]]
[[Category: nppsfa]]
[[Category: pdz domain]]
[[Category: pdz-rhogef]]
[[Category: rho guanine nucleotide exchange factor 11]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:28:46 2008''
Retrieved from "https://proteopedia.org/2dls"