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==Lysobacter enzymogenes lysc endoproteinase K30R mutant covalently inhibited by TLCK==
==Lysobacter enzymogenes lysc endoproteinase K30R mutant covalently inhibited by TLCK==
<StructureSection load='4nsv' size='340' side='right' caption='[[4nsv]], [[Resolution|resolution]] 0.90&Aring;' scene=''>
<StructureSection load='4nsv' size='340' side='right'caption='[[4nsv]], [[Resolution|resolution]] 0.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4nsv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_29487 Atcc 29487]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NSV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NSV FirstGlance]. <br>
<table><tr><td colspan='2'>[[4nsv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lysobacter_enzymogenes Lysobacter enzymogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NSV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2OY:N-[(2S,3S)-7-AMINO-1-CHLORO-2-HYDROXYHEPTAN-3-YL]-4-METHYLBENZENESULFONAMIDE+(BOUND+FORM)'>2OY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.9&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4nsy|4nsy]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2OY:N-[(2S,3S)-7-AMINO-1-CHLORO-2-HYDROXYHEPTAN-3-YL]-4-METHYLBENZENESULFONAMIDE+(BOUND+FORM)'>2OY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysyl_endopeptidase Lysyl endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.50 3.4.21.50] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nsv OCA], [https://pdbe.org/4nsv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nsv RCSB], [https://www.ebi.ac.uk/pdbsum/4nsv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nsv ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nsv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nsv RCSB], [http://www.ebi.ac.uk/pdbsum/4nsv PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/LYSC_LYSEN LYSC_LYSEN]] Highly specific endopeptidase that hydrolyzes lysyl bonds including the Lys-Pro bond.  
[https://www.uniprot.org/uniprot/LYSC_LYSEN LYSC_LYSEN] Highly specific endopeptidase that hydrolyzes lysyl bonds including the Lys-Pro bond.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4nsv" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 29487]]
[[Category: Large Structures]]
[[Category: Lysyl endopeptidase]]
[[Category: Lysobacter enzymogenes]]
[[Category: Asztalos, P]]
[[Category: Asztalos P]]
[[Category: Holke, W]]
[[Category: Holke W]]
[[Category: Muller, A]]
[[Category: Muller A]]
[[Category: Rudolph, M G]]
[[Category: Rudolph MG]]
[[Category: Sobek, H]]
[[Category: Sobek H]]
[[Category: Aromatic stack]]
[[Category: Atomic resolution]]
[[Category: Catalytic triad]]
[[Category: Covalent inhibition]]
[[Category: Endoproteinase]]
[[Category: Hydrolase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Serine protease]]
[[Category: Tlck]]
Retrieved from "https://proteopedia.org/4nsv"