2e19: Difference between revisions

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[[Image:2e19.jpg|left|200px]]


{{Structure
==Solution structure of the homeobox domain from human NIL-2-A zinc finger protein, transcription factor 8==
|PDB= 2e19 |SIZE=350|CAPTION= <scene name='initialview01'>2e19</scene>
<StructureSection load='2e19' size='340' side='right'caption='[[2e19]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[2e19]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E19 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E19 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
|GENE= TCF8, AREB6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e19 OCA], [https://pdbe.org/2e19 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e19 RCSB], [https://www.ebi.ac.uk/pdbsum/2e19 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e19 ProSAT], [https://www.topsan.org/Proteins/RSGI/2e19 TOPSAN]</span></td></tr>
}}
</table>
 
== Disease ==
'''Solution structure of the homeobox domain from human NIL-2-A zinc finger protein, transcription factor 8'''
[https://www.uniprot.org/uniprot/ZEB1_HUMAN ZEB1_HUMAN] Fuchs endothelial corneal dystrophy;Posterior polymorphous corneal dystrophy. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
 
== Function ==
 
[https://www.uniprot.org/uniprot/ZEB1_HUMAN ZEB1_HUMAN] Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.<ref>PMID:19935649</ref> <ref>PMID:20175752</ref> <ref>PMID:20418909</ref>
==Disease==
== Evolutionary Conservation ==
Known disease associated with this structure: Corneal dystrophy, posterior polymorphous, 3 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=189909 189909]]
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
==About this Structure==
  <jmolCheckbox>
2E19 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E19 OCA].  
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e1/2e19_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e19 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Harada, T.]]
[[Category: Harada T]]
[[Category: Kigawa, T.]]
[[Category: Kigawa T]]
[[Category: Koshiba, S.]]
[[Category: Koshiba S]]
[[Category: Ohnishi, S.]]
[[Category: Ohnishi S]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Tochio N]]
[[Category: Tochio, N.]]
[[Category: Watanabe S]]
[[Category: Watanabe, S.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: homeobox domain]]
[[Category: national project on protein structural and functional analyse]]
[[Category: nppsfa]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomic]]
[[Category: transcription factor]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:33:58 2008''

Latest revision as of 18:46, 29 May 2024

Solution structure of the homeobox domain from human NIL-2-A zinc finger protein, transcription factor 8

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