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==Crystal structure of Danio rerio MEC-17 catalytic domain in complex with acetyl-CoA==
==Crystal structure of Danio rerio MEC-17 catalytic domain in complex with acetyl-CoA==
<StructureSection load='4hkf' size='340' side='right' caption='[[4hkf]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='4hkf' size='340' side='right'caption='[[4hkf]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4hkf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HKF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HKF FirstGlance]. <br>
<table><tr><td colspan='2'>[[4hkf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HKF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">atat1, mec17, si:ch211-152p11.5, zgc:65893 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Danio rerio])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hkf OCA], [https://pdbe.org/4hkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hkf RCSB], [https://www.ebi.ac.uk/pdbsum/4hkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hkf ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-tubulin_N-acetyltransferase Alpha-tubulin N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.108 2.3.1.108] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hkf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hkf RCSB], [http://www.ebi.ac.uk/pdbsum/4hkf PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ATAT_DANRE ATAT_DANRE]] Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. May promote directional cell locomotion and chemotaxis (By similarity). May be required for normal sperm flagellar function (By similarity). May affect microtubule stability and regulate microtubule dynamics. May be involved in neuron development. Acetylates alpha-tubulin in neurons, but not in cilia.[HAMAP-Rule:MF_03130]<ref>PMID:20829795</ref>
[https://www.uniprot.org/uniprot/ATAT_DANRE ATAT_DANRE] Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. May promote directional cell locomotion and chemotaxis (By similarity). May be required for normal sperm flagellar function (By similarity). May affect microtubule stability and regulate microtubule dynamics. May be involved in neuron development. Acetylates alpha-tubulin in neurons, but not in cilia.[HAMAP-Rule:MF_03130]<ref>PMID:20829795</ref>  
 
==See Also==
*[[Alpha-tubulin N-acetyltransferase 3D structures|Alpha-tubulin N-acetyltransferase 3D structures]]
*[[Tubulin acetyltransferase|Tubulin acetyltransferase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Alpha-tubulin N-acetyltransferase]]
[[Category: Danio rerio]]
[[Category: Danio rerio]]
[[Category: Ding, J]]
[[Category: Large Structures]]
[[Category: Li, W]]
[[Category: Ding J]]
[[Category: Sun, B]]
[[Category: Li W]]
[[Category: Xu, S]]
[[Category: Sun B]]
[[Category: Zhang, T]]
[[Category: Xu S]]
[[Category: Zhong, C]]
[[Category: Zhang T]]
[[Category: Acetyl-coa]]
[[Category: Zhong C]]
[[Category: Gnat]]
[[Category: Gnat fold]]
[[Category: Mec-17]]
[[Category: Transferase]]
[[Category: Tubulin acetyltransferase]]
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