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==Crystal Structure of the R21D mutant of alpha-spectrin SH3 domain. Crystal obtained in ammonium sulphate at pH 6.==
==Crystal Structure of the R21D mutant of alpha-spectrin SH3 domain. Crystal obtained in ammonium sulphate at pH 6.==
<StructureSection load='3m0r' size='340' side='right' caption='[[3m0r]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
<StructureSection load='3m0r' size='340' side='right'caption='[[3m0r]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3m0r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M0R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M0R FirstGlance]. <br>
<table><tr><td colspan='2'>[[3m0r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M0R FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1shg|1shg]], [[3i9q|3i9q]], [[2f2w|2f2w]], [[2f2x|2f2x]], [[3m0p|3m0p]], [[3m0q|3m0q]], [[3m0s|3m0s]], [[3m0t|3m0t]], [[3m0u|3m0u]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SPTAN1, SPTA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m0r OCA], [https://pdbe.org/3m0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m0r RCSB], [https://www.ebi.ac.uk/pdbsum/3m0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m0r ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m0r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m0r RCSB], [http://www.ebi.ac.uk/pdbsum/3m0r PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SPTA2_CHICK SPTA2_CHICK]] Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization.  
[https://www.uniprot.org/uniprot/SPTN1_CHICK SPTN1_CHICK] Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization.


==See Also==
==See Also==
*[[Spectrin|Spectrin]]
*[[Spectrin 3D structures|Spectrin 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Camara-Artigas, A]]
[[Category: Large Structures]]
[[Category: Gavira, J A]]
[[Category: Camara-Artigas A]]
[[Category: Actin capping]]
[[Category: Gavira JA]]
[[Category: Actin-binding]]
[[Category: Calmodulin-binding]]
[[Category: Cytoskeleton]]
[[Category: Phosphoprotein]]
[[Category: Sh3 domain]]
[[Category: Sh3-like barrel]]
[[Category: Signaling protein]]

Latest revision as of 06:36, 19 July 2023

Crystal Structure of the R21D mutant of alpha-spectrin SH3 domain. Crystal obtained in ammonium sulphate at pH 6.

3m0r, resolution 1.10Å

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