2e8p: Difference between revisions

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[[Image:2e8p.jpg|left|200px]]


{{Structure
==Solution structure of the N-terminal SAM-domain of E74-like factor 3==
|PDB= 2e8p |SIZE=350|CAPTION= <scene name='initialview01'>2e8p</scene>
<StructureSection load='2e8p' size='340' side='right'caption='[[2e8p]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[2e8p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E8P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E8P FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
|GENE= ELF3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= Homo sapiens])
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e8p OCA], [https://pdbe.org/2e8p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e8p RCSB], [https://www.ebi.ac.uk/pdbsum/2e8p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e8p ProSAT], [https://www.topsan.org/Proteins/RSGI/2e8p TOPSAN]</span></td></tr>
}}
</table>
 
== Function ==
'''Solution structure of the N-terminal SAM-domain of E74-like factor 3'''
[https://www.uniprot.org/uniprot/ELF3_HUMAN ELF3_HUMAN] Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity).<ref>PMID:9234700</ref> <ref>PMID:9336459</ref> <ref>PMID:9129154</ref> <ref>PMID:9395241</ref> <ref>PMID:9417054</ref> <ref>PMID:10391676</ref> <ref>PMID:10644990</ref> <ref>PMID:10773884</ref> <ref>PMID:11036073</ref> <ref>PMID:11313868</ref> <ref>PMID:12713734</ref> <ref>PMID:12414801</ref> <ref>PMID:12624109</ref> <ref>PMID:12682075</ref> <ref>PMID:14715662</ref> <ref>PMID:15075319</ref> <ref>PMID:15169914</ref> <ref>PMID:14767472</ref> <ref>PMID:15794755</ref> <ref>PMID:16307850</ref> <ref>PMID:17060315</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==About this Structure==
Check<jmol>
2E8P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E8P OCA].  
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e8/2e8p_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e8p ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Goroncy, A K.]]
[[Category: Goroncy AK]]
[[Category: Harada, T.]]
[[Category: Harada T]]
[[Category: Kigawa, T.]]
[[Category: Kigawa T]]
[[Category: Koshiba, S.]]
[[Category: Koshiba S]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Sato M]]
[[Category: Sato, M.]]
[[Category: Watanabe S]]
[[Category: Watanabe, S.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: cell-free protein synthesis]]
[[Category: national project on protein structural and functional analyse]]
[[Category: nppsfa]]
[[Category: protein regulation]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:36:48 2008''
Retrieved from "https://proteopedia.org/2e8p"