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[[Image:2ebl.jpg|left|200px]]


{{Structure
==Solution structure of the Zinc finger, C4-type domain of human COUP transcription factor 1==
|PDB= 2ebl |SIZE=350|CAPTION= <scene name='initialview01'>2ebl</scene>
<StructureSection load='2ebl' size='340' side='right'caption='[[2ebl]]' scene=''>
|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Residue+A+191'>AC1</scene> and <scene name='pdbsite=AC2:Zn+Binding+Site+For+Residue+A+241'>AC2</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene>
<table><tr><td colspan='2'>[[2ebl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EBL FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
|GENE= NR2F1, EAR3, ERBAL3, TFCOUP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ebl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ebl OCA], [https://pdbe.org/2ebl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ebl RCSB], [https://www.ebi.ac.uk/pdbsum/2ebl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ebl ProSAT], [https://www.topsan.org/Proteins/RSGI/2ebl TOPSAN]</span></td></tr>
 
</table>
'''Solution structure of the Zinc finger, C4-type domain of human COUP transcription factor 1'''
== Function ==
 
[https://www.uniprot.org/uniprot/COT1_HUMAN COT1_HUMAN] Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG.<ref>PMID:10644740</ref> <ref>PMID:11682620</ref>
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
2EBL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EBL OCA].  
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eb/2ebl_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ebl ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Harada, T.]]
[[Category: Harada T]]
[[Category: Kigawa, T.]]
[[Category: Kigawa T]]
[[Category: Koshiba, S.]]
[[Category: Koshiba S]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Watabe S]]
[[Category: Watabe, S.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: Yoneyama M]]
[[Category: Yoneyama, M.]]
[[Category: ZN]]
[[Category: dna-binding]]
[[Category: ear3]]
[[Category: erbal3]]
[[Category: metal-binding]]
[[Category: national project on protein structural and functional analyse]]
[[Category: nppsfa]]
[[Category: nuclear protein]]
[[Category: receptor]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomic]]
[[Category: tfcoup1]]
[[Category: transcription]]
[[Category: transcription regulation]]
[[Category: zinc]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:37:54 2008''

Latest revision as of 18:48, 29 May 2024

Solution structure of the Zinc finger, C4-type domain of human COUP transcription factor 1

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