2ecb: Difference between revisions

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[[Image:2ecb.jpg|left|200px]]


{{Structure
==The solution structure of the third homeobox domain of human zinc fingers and homeoboxes protein==
|PDB= 2ecb |SIZE=350|CAPTION= <scene name='initialview01'>2ecb</scene>
<StructureSection load='2ecb' size='340' side='right'caption='[[2ecb]]' scene=''>
|SITE=
== Structural highlights ==
|LIGAND=
<table><tr><td colspan='2'>[[2ecb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2djo 2djo]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ECB FirstGlance]. <br>
|ACTIVITY=
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
|GENE= ZHX1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ecb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ecb OCA], [https://pdbe.org/2ecb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ecb RCSB], [https://www.ebi.ac.uk/pdbsum/2ecb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ecb ProSAT], [https://www.topsan.org/Proteins/RSGI/2ecb TOPSAN]</span></td></tr>
}}
</table>
 
== Function ==
'''The solution structure of the third homeobox domain of human zinc fingers and homeoboxes protein'''
[https://www.uniprot.org/uniprot/ZHX1_HUMAN ZHX1_HUMAN] Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins.<ref>PMID:12237128</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==About this Structure==
Check<jmol>
2ECB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry 2DJO. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECB OCA].  
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/2ecb_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ecb ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Inoue, M.]]
[[Category: Inoue M]]
[[Category: Kigawa, T.]]
[[Category: Kigawa T]]
[[Category: Koshiba, S.]]
[[Category: Koshiba S]]
[[Category: Ohnishi, S.]]
[[Category: Ohnishi S]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Saito K]]
[[Category: Saito, K.]]
[[Category: Sasagawa A]]
[[Category: Sasagawa, A.]]
[[Category: Tochio N]]
[[Category: Tochio, N.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: homeobox domain]]
[[Category: national project on protein structural and functional analyse]]
[[Category: nmr]]
[[Category: nppsfa]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomic]]
[[Category: transcription factor]]
[[Category: zinc fingers and homeoboxes protein]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:38:10 2008''
Retrieved from "https://proteopedia.org/2ecb"