2ecm: Difference between revisions

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[[Image:2ecm.jpg|left|200px]]


{{Structure
==Solution structure of the RING domain of the RING finger and CHY zinc finger domain-containing protein 1 from Mus musculus==
|PDB= 2ecm |SIZE=350|CAPTION= <scene name='initialview01'>2ecm</scene>
<StructureSection load='2ecm' size='340' side='right'caption='[[2ecm]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene>
<table><tr><td colspan='2'>[[2ecm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ECM FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
|GENE= Rchy1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ecm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ecm OCA], [https://pdbe.org/2ecm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ecm RCSB], [https://www.ebi.ac.uk/pdbsum/2ecm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ecm ProSAT], [https://www.topsan.org/Proteins/RSGI/2ecm TOPSAN]</span></td></tr>
 
</table>
'''Solution structure of the RING domain of the RING finger and CHY zinc finger domain-containing protein 1 from Mus musculus'''
== Function ==
 
[https://www.uniprot.org/uniprot/ZN363_MOUSE ZN363_MOUSE] Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Increases AR transcription factor activity. Monoubiquitinates the translesion DNA polymerase POLH (By similarity). Contributes to the regulation of the cell cycle progression.
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
2ECM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECM OCA].  
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/2ecm_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ecm ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Harada T]]
[[Category: Harada, T.]]
[[Category: Kigawa T]]
[[Category: Kigawa, T.]]
[[Category: Koshiba S]]
[[Category: Koshiba, S.]]
[[Category: Miyamoto K]]
[[Category: Miyamoto, K.]]
[[Category: Watanabe S]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Yokoyama S]]
[[Category: Watanabe, S.]]
[[Category: Yoneyama M]]
[[Category: Yokoyama, S.]]
[[Category: Yoneyama, M.]]
[[Category: ZN]]
[[Category: metal binding protein]]
[[Category: national project on protein structural and functional analyse]]
[[Category: nppsfa]]
[[Category: rchy1]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: ring domain]]
[[Category: ring finger and chy zinc finger domain-containing protein 1]]
[[Category: rsgi]]
[[Category: structural genomic]]
[[Category: zinc-binding domain]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:38:18 2008''
Retrieved from "https://proteopedia.org/2ecm"