2efa: Difference between revisions

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[[Image:2efa.jpg|left|200px]]


{{Structure
==Neutron crystal structure of cubic insulin at pD6.6==
|PDB= 2efa |SIZE=350|CAPTION= <scene name='initialview01'>2efa</scene>, resolution 2.7&Aring;
<StructureSection load='2efa' size='340' side='right'caption='[[2efa]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene> and <scene name='pdbligand=DOD:DEUTERATED WATER'>DOD</scene>
<table><tr><td colspan='2'>[[2efa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EFA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EFA FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Neutron Diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2efa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2efa OCA], [https://pdbe.org/2efa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2efa RCSB], [https://www.ebi.ac.uk/pdbsum/2efa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2efa ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/INS_PIG INS_PIG] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ef/2efa_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2efa ConSurf].
<div style="clear:both"></div>


'''Neutron crystal structure of cubic insulin at pD6.6'''
==See Also==
 
*[[Insulin 3D Structures|Insulin 3D Structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2EFA is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EFA OCA].
[[Category: Large Structures]]
[[Category: Protein complex]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
[[Category: Ishikawa, T.]]
[[Category: Ishikawa T]]
[[Category: Niimura, N.]]
[[Category: Niimura N]]
[[Category: Tanaka, I.]]
[[Category: Tanaka I]]
[[Category: DOD]]
[[Category: cubic porcine insulin]]
[[Category: hormone]]
[[Category: hormone/growth factor complex]]
[[Category: neutron diffraction]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:39:21 2008''
Retrieved from "https://proteopedia.org/2efa"