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==Crystal structure of IPM isomerase large subunit from methanococcus jannaschii (MJ0499)==
==Crystal structure of IPM isomerase large subunit from methanococcus jannaschii (MJ0499)==
<StructureSection load='4kp1' size='340' side='right' caption='[[4kp1]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='4kp1' size='340' side='right'caption='[[4kp1]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4kp1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Metja Metja]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KP1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KP1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4kp1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii_DSM_2661 Methanocaldococcus jannaschii DSM 2661]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KP1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KP1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KP1:2,4-DIMETHYLPENTANE-2,4-DIOL'>KP1</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KP1:2,4-DIMETHYLPENTANE-2,4-DIOL'>KP1</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">leuC, MJ0499 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243232 METJA])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kp1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kp1 OCA], [https://pdbe.org/4kp1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kp1 RCSB], [https://www.ebi.ac.uk/pdbsum/4kp1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kp1 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kp1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kp1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kp1 RCSB], [http://www.ebi.ac.uk/pdbsum/4kp1 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/LEUC_METJA LEUC_METJA]] Enzyme with broad specificity that catalyzes reversible hydroxyacid isomerizations via dehydration/hydration reactions. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate, a step involved in leucine biosynthesis. Catalyzes the isomerization between 2-methylmalate and 3-methylmalate, via the formation of 2-methylmaleate (citraconate), a step involved in isoleucine biosynthesis. Also displays malease activity, i.e. catalyzes the hydration of maleate to form (R)-malate.<ref>PMID:17449626</ref> 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4kp1" style="background-color:#fffaf0;"></div>
==See Also==
*[[Isopropylmalate isomerase|Isopropylmalate isomerase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Metja]]
[[Category: Large Structures]]
[[Category: Hwang, K Y]]
[[Category: Methanocaldococcus jannaschii DSM 2661]]
[[Category: Lee, E H]]
[[Category: Hwang KY]]
[[Category: Aconitase family]]
[[Category: Lee EH]]
[[Category: Alpha-beta-alpha 3-layer sandwich]]
[[Category: Iron-sulfur cluster binding]]
[[Category: Isomerase]]
Retrieved from "https://proteopedia.org/4kp1"