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==Crystal structure of human two pore domain potassium ion channel TREK1 (K2P2.1)==
==Crystal structure of human two pore domain potassium ion channel TREK1 (K2P2.1)==
<StructureSection load='4twk' size='340' side='right' caption='[[4twk]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='4twk' size='340' side='right'caption='[[4twk]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4twk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TWK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TWK FirstGlance]. <br>
<table><tr><td colspan='2'>[[4twk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TWK FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=37X:OCTYL+GLUCOSE+NEOPENTYL+GLYCOL'>37X</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4twk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4twk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4twk RCSB], [http://www.ebi.ac.uk/pdbsum/4twk PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=37X:OCTYL+GLUCOSE+NEOPENTYL+GLYCOL'>37X</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4twk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4twk OCA], [https://pdbe.org/4twk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4twk RCSB], [https://www.ebi.ac.uk/pdbsum/4twk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4twk ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/KCNK2_HUMAN KCNK2_HUMAN]] Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner.<ref>PMID:10784345</ref> <ref>PMID:24196565</ref> <ref>PMID:11319556</ref>  Isoform 4: Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2 (By similarity).<ref>PMID:10784345</ref> <ref>PMID:24196565</ref> <ref>PMID:11319556</ref>
[https://www.uniprot.org/uniprot/KCNK2_HUMAN KCNK2_HUMAN] Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner.<ref>PMID:10784345</ref> <ref>PMID:24196565</ref> <ref>PMID:11319556</ref>  Isoform 4: Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2 (By similarity).<ref>PMID:10784345</ref> <ref>PMID:24196565</ref> <ref>PMID:11319556</ref>  
 
==See Also==
*[[Potassium channel 3D structures|Potassium channel 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ang, J H]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H]]
[[Category: Large Structures]]
[[Category: Berridge, G]]
[[Category: Ang JH]]
[[Category: Bountra, C]]
[[Category: Arrowsmith CH]]
[[Category: Burgess-Brown, N A]]
[[Category: Berridge G]]
[[Category: Bushell, S R]]
[[Category: Bountra C]]
[[Category: Carpenter, E P]]
[[Category: Burgess-Brown NA]]
[[Category: Chalk, R]]
[[Category: Bushell SR]]
[[Category: Chu, A]]
[[Category: Carpenter EP]]
[[Category: Delft, F von]]
[[Category: Chalk R]]
[[Category: Dong, L]]
[[Category: Chu A]]
[[Category: Dong, Y Y]]
[[Category: Dong L]]
[[Category: Edwards, A M]]
[[Category: Dong YY]]
[[Category: Faust, B]]
[[Category: Edwards AM]]
[[Category: Goubin, S]]
[[Category: Faust B]]
[[Category: Grieben, M]]
[[Category: Goubin S]]
[[Category: Kupinska, K]]
[[Category: Grieben M]]
[[Category: Mackenzie, A]]
[[Category: Kupinska K]]
[[Category: Mukhopadhyay, S]]
[[Category: Mackenzie A]]
[[Category: Pike, A C.W]]
[[Category: Mukhopadhyay S]]
[[Category: Quigley, A]]
[[Category: Pike ACW]]
[[Category: Shintre, C A]]
[[Category: Quigley A]]
[[Category: Shrestha, L]]
[[Category: Shintre CA]]
[[Category: Strain-Damerell, C]]
[[Category: Shrestha L]]
[[Category: Tessitore, A]]
[[Category: Strain-Damerell C]]
[[Category: Wang, D]]
[[Category: Tessitore A]]
[[Category: Ion channel]]
[[Category: Wang D]]
[[Category: K2p]]
[[Category: Von Delft F]]
[[Category: Membrane protein]]
[[Category: Transport protein]]
Retrieved from "https://proteopedia.org/4twk"