4c9v: Difference between revisions

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==Xenopus RNF43 ectodomain in complex with Xenopus RSPO2 Fu1-Fu2==
==Xenopus RNF43 ectodomain in complex with Xenopus RSPO2 Fu1-Fu2==
<StructureSection load='4c9v' size='340' side='right' caption='[[4c9v]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='4c9v' size='340' side='right'caption='[[4c9v]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4c9v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Silurana_(xenopus)_tropicalis Silurana (xenopus) tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C9V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C9V FirstGlance]. <br>
<table><tr><td colspan='2'>[[4c9v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_tropicalis Xenopus tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C9V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C9V FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4c84|4c84]], [[4c85|4c85]], [[4c86|4c86]], [[4c8a|4c8a]], [[4c8c|4c8c]], [[4c8f|4c8f]], [[4c8p|4c8p]], [[4c8t|4c8t]], [[4c8u|4c8u]], [[4c8v|4c8v]], [[4c8w|4c8w]], [[4c99|4c99]], [[4c9a|4c9a]], [[4c9e|4c9e]], [[4c9r|4c9r]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c9v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c9v RCSB], [http://www.ebi.ac.uk/pdbsum/4c9v PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c9v OCA], [https://pdbe.org/4c9v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c9v RCSB], [https://www.ebi.ac.uk/pdbsum/4c9v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c9v ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RSPO2_XENTR RSPO2_XENTR]] Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical. Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway. Activates neural markers and promotes muscle formation. Overexpression blocks activin, nodal and BMP4 signaling, suggesting that it may negatively regulate the TGF-beta pathway (By similarity).  
[https://www.uniprot.org/uniprot/RSPO2_XENTR RSPO2_XENTR] Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical. Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway. Activates neural markers and promotes muscle formation. Overexpression blocks activin, nodal and BMP4 signaling, suggesting that it may negatively regulate the TGF-beta pathway (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4c9v" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Jones, E Y]]
[[Category: Large Structures]]
[[Category: Zebisch, M]]
[[Category: Xenopus tropicalis]]
[[Category: Lgr4]]
[[Category: Jones EY]]
[[Category: Lgr5]]
[[Category: Zebisch M]]
[[Category: Lgr6]]
[[Category: Membrane]]
[[Category: R-spo]]
[[Category: R-spondin]]
[[Category: Receptor]]
[[Category: Rnf43]]
[[Category: Rspo]]
[[Category: Rspo1]]
[[Category: Rspo2]]
[[Category: Rspo3]]
[[Category: Rspo4]]
[[Category: Signaling protein]]
[[Category: Signalling]]
[[Category: Wnt]]
[[Category: Znrf3]]
Retrieved from "https://proteopedia.org/4c9v"