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[[Image:2erx.gif|left|200px]]


{{Structure
==Crystal Structure of DiRas2 in Complex With GDP and Inorganic Phosphate==
|PDB= 2erx |SIZE=350|CAPTION= <scene name='initialview01'>2erx</scene>, resolution 1.65&Aring;
<StructureSection load='2erx' size='340' side='right'caption='[[2erx]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=GDP:GUANOSINE-5'-DIPHOSPHATE'>GDP</scene>
<table><tr><td colspan='2'>[[2erx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ERX FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
|GENE= DIRAS2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2erx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2erx OCA], [https://pdbe.org/2erx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2erx RCSB], [https://www.ebi.ac.uk/pdbsum/2erx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2erx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DIRA2_HUMAN DIRA2_HUMAN] Displays low GTPase activity and exist predominantly in the GTP-bound form.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/er/2erx_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2erx ConSurf].
<div style="clear:both"></div>


'''Crystal Structure of DiRas2 in Complex With GDP and Inorganic Phosphate'''
==See Also==
 
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2ERX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERX OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C.]]
[[Category: Arrowsmith C]]
[[Category: Ball, L J.]]
[[Category: Ball LJ]]
[[Category: Burgess, N.]]
[[Category: Burgess N]]
[[Category: Delft, F von.]]
[[Category: Doyle D]]
[[Category: Doyle, D.]]
[[Category: Edwards A]]
[[Category: Edwards, A.]]
[[Category: Elkins J]]
[[Category: Elkins, J.]]
[[Category: Fedorov O]]
[[Category: Fedorov, O.]]
[[Category: Niesen FE]]
[[Category: Niesen, F E.]]
[[Category: Papagrigoriou E]]
[[Category: Papagrigoriou, E.]]
[[Category: Salah E]]
[[Category: Salah, E.]]
[[Category: Sundstrom M]]
[[Category: Sundstrom, M.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: Yang X]]
[[Category: Yang, X.]]
[[Category: Von Delft F]]
[[Category: GDP]]
[[Category: MG]]
[[Category: PO4]]
[[Category: diras2]]
[[Category: gtp hydrolysis]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:43:43 2008''
Retrieved from "https://proteopedia.org/2erx"