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[[Image:2est.jpg|left|200px]]


{{Structure
==Crystallographic study of the binding of a trifluoroacetyl dipeptide anilide inhibitor with elastase==
|PDB= 2est |SIZE=350|CAPTION= <scene name='initialview01'>2est</scene>, resolution 2.5&Aring;
<StructureSection load='2est' size='340' side='right'caption='[[2est]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
<table><tr><td colspan='2'>[[2est]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EST OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EST FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2Z5:6-AMMONIO-N-(TRIFLUOROACETYL)-L-NORLEUCYL-N-[4-(TRIFLUOROMETHYL)PHENYL]-L-ALANINAMIDE'>2Z5</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2est FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2est OCA], [https://pdbe.org/2est PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2est RCSB], [https://www.ebi.ac.uk/pdbsum/2est PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2est ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CELA1_PIG CELA1_PIG] Acts upon elastin.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/es/2est_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2est ConSurf].
<div style="clear:both"></div>


'''CRYSTALLOGRAPHIC STUDY OF THE BINDING OF A TRIFLUOROACETYL DIPEPTIDE ANILIDE INHIBITOR WITH ELASTASE'''
==See Also==
 
*[[Elastase 3D structures|Elastase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2EST is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EST OCA].
[[Category: Large Structures]]
 
==Reference==
Crystallographic study of the binding of a trifluoroacetyl dipeptide anilide inhibitor with elastase., Hughes DL, Sieker LC, Bieth J, Dimicoli JL, J Mol Biol. 1982 Dec 15;162(3):645-58. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/6926029 6926029]
[[Category: Pancreatic elastase]]
[[Category: Single protein]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
[[Category: Hughes, D L.]]
[[Category: Hughes DL]]
[[Category: Sieker, L C.]]
[[Category: Sieker LC]]
[[Category: SO4]]
[[Category: hydrolase (serine proteinase)]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:44:00 2008''
Retrieved from "https://proteopedia.org/2est"