2exg: Difference between revisions

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[[Image:2exg.gif|left|200px]]


{{Structure
==Making Protein-Protein Interactions Drugable: Discovery of Low-Molecular-Weight Ligands for the AF6 PDZ Domain==
|PDB= 2exg |SIZE=350|CAPTION= <scene name='initialview01'>2exg</scene>
<StructureSection load='2exg' size='340' side='right'caption='[[2exg]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=STF:(5R)-2-SULFANYL-5-[4-(TRIFLUOROMETHYL)BENZYL]-1,3-THIAZOL-4-ONE'>STF</scene>
<table><tr><td colspan='2'>[[2exg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EXG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EXG FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=STF:(5R)-2-SULFANYL-5-[4-(TRIFLUOROMETHYL)BENZYL]-1,3-THIAZOL-4-ONE'>STF</scene></td></tr>
|GENE=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2exg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2exg OCA], [https://pdbe.org/2exg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2exg RCSB], [https://www.ebi.ac.uk/pdbsum/2exg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2exg ProSAT]</span></td></tr>
}}
</table>
 
== Disease ==
'''Making Protein-Protein Interactions Drugable: Discovery of Low-Molecular-Weight Ligands for the AF6 PDZ Domain'''
[[https://www.uniprot.org/uniprot/AFAD_HUMAN AFAD_HUMAN]] Note=A chromosomal aberration involving MLLT4 is associated with acute leukemias. Translocation t(6;11)(q27;q23) with MLL/HRX. The result is a rogue activator protein.
 
== Function ==
 
[[https://www.uniprot.org/uniprot/AFAD_HUMAN AFAD_HUMAN]] Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton.  
==About this Structure==
== Evolutionary Conservation ==
2EXG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EXG OCA].  
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
==Reference==
  <jmolCheckbox>
Discovery of low-molecular-weight ligands for the AF6 PDZ domain., Joshi M, Vargas C, Boisguerin P, Diehl A, Krause G, Schmieder P, Moelling K, Hagen V, Schade M, Oschkinat H, Angew Chem Int Ed Engl. 2006 Jun 2;45(23):3790-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16671149 16671149]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ex/2exg_consurf.spt"</scriptWhenChecked>
[[Category: Homo sapiens]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Single protein]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Boisguerin, P.]]
  </jmolCheckbox>
[[Category: Joshi, M.]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2exg ConSurf].
[[Category: Krause, G.]]
<div style="clear:both"></div>
[[Category: Oschkinat, H.]]
__TOC__
[[Category: Schade, M.]]
</StructureSection>
[[Category: Vargas, C.]]
[[Category: Human]]
[[Category: STF]]
[[Category: Large Structures]]
[[Category: inhibitors of protein-protein interaction]]
[[Category: Boisguerin, P]]
[[Category: low-molecular-weight ligand]]
[[Category: Joshi, M]]
[[Category: nmr screening]]
[[Category: Krause, G]]
[[Category: pdz domain]]
[[Category: Oschkinat, H]]
[[Category: protein structure]]
[[Category: Schade, M]]
 
[[Category: Vargas, C]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:45:35 2008''
[[Category: Cell adhesion]]
[[Category: Inhibitors of protein-protein interaction]]
[[Category: Low-molecular-weight ligand]]
[[Category: Nmr screening]]
[[Category: Pdz domain]]
[[Category: Protein structure]]
Retrieved from "https://proteopedia.org/2exg"