2f15: Difference between revisions

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[[Image:2f15.gif|left|200px]]


{{Structure
==Glycogen-Binding Domain Of The Amp-Activated Protein Kinase beta2 Subunit==
|PDB= 2f15 |SIZE=350|CAPTION= <scene name='initialview01'>2f15</scene>, resolution 2.00&Aring;
<StructureSection load='2f15' size='340' side='right'caption='[[2f15]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[2f15]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F15 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F15 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
|GENE= PRKAB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f15 OCA], [https://pdbe.org/2f15 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f15 RCSB], [https://www.ebi.ac.uk/pdbsum/2f15 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f15 ProSAT]</span></td></tr>
}}
</table>
== Function ==
[https://www.uniprot.org/uniprot/AAKB2_HUMAN AAKB2_HUMAN] Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f1/2f15_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f15 ConSurf].
<div style="clear:both"></div>


'''Glycogen-Binding Domain Of The Amp-Activated Protein Kinase beta2 Subunit'''
==See Also==
 
*[[AMP-activated protein kinase 3D structures|AMP-activated protein kinase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2F15 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F15 OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C.]]
[[Category: Arrowsmith C]]
[[Category: Bochkarev, A.]]
[[Category: Bochkarev A]]
[[Category: Dhe-Paganon, S.]]
[[Category: Dhe-Paganon S]]
[[Category: Edwards, A.]]
[[Category: Edwards A]]
[[Category: Jr., P J.Finerty.]]
[[Category: Finerty Jr PJ]]
[[Category: MacKenzie, F M.]]
[[Category: MacKenzie FM]]
[[Category: Newman, E.]]
[[Category: Newman E]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Sundstrom M]]
[[Category: Sundstrom, M.]]
[[Category: Walker JR]]
[[Category: Walker, J R.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: Wybenga-Groot L]]
[[Category: Wybenga-Groot, L.]]
[[Category: beta sandwich]]
[[Category: fatty acid biosynthesis]]
[[Category: lipid synthesis]]
[[Category: phosphorylation]]
[[Category: sgc]]
[[Category: structural genomics consortium]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:46:51 2008''
Retrieved from "https://proteopedia.org/2f15"