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==Crystal structure of Peptidyl-tRNA hydrolase from a Gram-positive bacterium, Streptococcus pyogenes at 2.19 Angstrom resolution shows the Closed Structure of the Substrate Binding Cleft==
==Crystal structure of Peptidyl-tRNA hydrolase from a Gram-positive bacterium, Streptococcus pyogenes at 2.19 Angstrom resolution shows the Closed Structure of the Substrate Binding Cleft==
<StructureSection load='4qt4' size='340' side='right' caption='[[4qt4]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
<StructureSection load='4qt4' size='340' side='right'caption='[[4qt4]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4qt4]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4q55 4q55]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QT4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QT4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4qt4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_NZ131 Streptococcus pyogenes NZ131]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4q55 4q55]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QT4 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jc4|4jc4]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.19&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoacyl-tRNA_hydrolase Aminoacyl-tRNA hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.29 3.1.1.29] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qt4 OCA], [https://pdbe.org/4qt4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qt4 RCSB], [https://www.ebi.ac.uk/pdbsum/4qt4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qt4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qt4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qt4 RCSB], [http://www.ebi.ac.uk/pdbsum/4qt4 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PTH_STRPZ PTH_STRPZ]] The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis (By similarity).  
[https://www.uniprot.org/uniprot/PTH_STRPZ PTH_STRPZ] The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4qt4" style="background-color:#fffaf0;"></div>
==See Also==
*[[Peptidyl-tRNA hydrolase|Peptidyl-tRNA hydrolase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Aminoacyl-tRNA hydrolase]]
[[Category: Large Structures]]
[[Category: Bhushan, A]]
[[Category: Streptococcus pyogenes NZ131]]
[[Category: Gautam, L]]
[[Category: Bhushan A]]
[[Category: Kaur, P]]
[[Category: Gautam L]]
[[Category: Sharma, S]]
[[Category: Kaur P]]
[[Category: Singh, A]]
[[Category: Sharma S]]
[[Category: Singh, T P]]
[[Category: Singh A]]
[[Category: Sinha, M]]
[[Category: Singh TP]]
[[Category: Hydrolase]]
[[Category: Sinha M]]
[[Category: Peptidyl-trna]]
[[Category: Pth]]