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==Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-5-077==
==Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-5-077==
<StructureSection load='3w7c' size='340' side='right' caption='[[3w7c]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
<StructureSection load='3w7c' size='340' side='right'caption='[[3w7c]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3w7c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycc Trycc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W7C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3W7C FirstGlance]. <br>
<table><tr><td colspan='2'>[[3w7c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi_strain_CL_Brener Trypanosoma cruzi strain CL Brener]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W7C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W7C FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene>, <scene name='pdbligand=W7C:5-[2-(5-METHOXYNAPHTHALEN-2-YL)ETHYL]-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC+ACID'>W7C</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3w1a|3w1a]], [[3w1l|3w1l]], [[3w1m|3w1m]], [[3w1n|3w1n]], [[3w1p|3w1p]], [[3w1q|3w1q]], [[3w1r|3w1r]], [[3w1t|3w1t]], [[3w1u|3w1u]], [[3w1x|3w1x]], [[3w22|3w22]], [[3w23|3w23]], [[3w2j|3w2j]], [[3w2k|3w2k]], [[3w2l|3w2l]], [[3w2m|3w2m]], [[3w2n|3w2n]], [[3w2u|3w2u]], [[4jd4|4jd4]], [[4jdb|4jdb]], [[3w6y|3w6y]], [[3w70|3w70]], [[3w71|3w71]], [[3w72|3w72]], [[3w73|3w73]], [[3w74|3w74]], [[3w75|3w75]], [[3w76|3w76]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene>, <scene name='pdbligand=W7C:5-[2-(5-METHOXYNAPHTHALEN-2-YL)ETHYL]-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC+ACID'>W7C</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PyrD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=353153 TRYCC])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w7c OCA], [https://pdbe.org/3w7c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w7c RCSB], [https://www.ebi.ac.uk/pdbsum/3w7c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w7c ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_oxidase_(fumarate) Dihydroorotate oxidase (fumarate)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.98.1 1.3.98.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w7c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3w7c RCSB], [http://www.ebi.ac.uk/pdbsum/3w7c PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PYRD_TRYCC PYRD_TRYCC]] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.  
[https://www.uniprot.org/uniprot/PYRD_TRYCC PYRD_TRYCC] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.
 
==See Also==
*[[Dihydroorotate dehydrogenase 3D structures|Dihydroorotate dehydrogenase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Trycc]]
[[Category: Large Structures]]
[[Category: Aoki, T]]
[[Category: Trypanosoma cruzi strain CL Brener]]
[[Category: Balogun, E O]]
[[Category: Aoki T]]
[[Category: Harada, S]]
[[Category: Balogun EO]]
[[Category: Hashimoto, S]]
[[Category: Harada S]]
[[Category: Honma, T]]
[[Category: Hashimoto S]]
[[Category: Iida, M]]
[[Category: Honma T]]
[[Category: Inaoka, D K]]
[[Category: Iida M]]
[[Category: Inoue, M]]
[[Category: Inaoka DK]]
[[Category: Kita, K]]
[[Category: Inoue M]]
[[Category: Kuranaga, T]]
[[Category: Kita K]]
[[Category: Lee, N]]
[[Category: Kuranaga T]]
[[Category: Matsuoka, S]]
[[Category: Lee N]]
[[Category: Nara, T]]
[[Category: Matsuoka S]]
[[Category: Sakamoto, K]]
[[Category: Nara T]]
[[Category: Shiba, T]]
[[Category: Sakamoto K]]
[[Category: Suzuki, S]]
[[Category: Shiba T]]
[[Category: Tabuchi, T]]
[[Category: Suzuki S]]
[[Category: Tanaka, A]]
[[Category: Tabuchi T]]
[[Category: Cytosol]]
[[Category: Tanaka A]]
[[Category: Dihydroorotate/orotate and fumarate/succinate binding]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
[[Category: Rossmann fold]]

Latest revision as of 12:55, 8 November 2023

Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-5-077

3w7c, resolution 1.75Å

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