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==Solution NMR structure of the SANT domain of human DNAJC2, Northeast structural genomics consortium target HR8254a==
==Solution NMR structure of the SANT domain of human DNAJC2, Northeast structural genomics consortium target HR8254a==
<StructureSection load='2m2e' size='340' side='right' caption='[[2m2e]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2m2e' size='340' side='right'caption='[[2m2e]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2m2e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M2E FirstGlance]. <br>
<table><tr><td colspan='2'>[[2m2e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M2E FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DNAJC2, MPHOSPH11, MPP11, ZRF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m2e RCSB], [http://www.ebi.ac.uk/pdbsum/2m2e PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2e OCA], [https://pdbe.org/2m2e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m2e RCSB], [https://www.ebi.ac.uk/pdbsum/2m2e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m2e ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DNJC2_HUMAN DNJC2_HUMAN]] Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'.<ref>PMID:16002468</ref> <ref>PMID:15802566</ref> <ref>PMID:21179169</ref>
[https://www.uniprot.org/uniprot/DNJC2_HUMAN DNJC2_HUMAN] Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'.<ref>PMID:16002468</ref> <ref>PMID:15802566</ref> <ref>PMID:21179169</ref>  
 
==See Also==
*[[DnaJ homolog 3D structures|DnaJ homolog 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C]]
[[Category: Large Structures]]
[[Category: Garcia, M]]
[[Category: Arrowsmith C]]
[[Category: Houliston, S]]
[[Category: Garcia M]]
[[Category: Lemak, A]]
[[Category: Houliston S]]
[[Category: Montelione, G T]]
[[Category: Lemak A]]
[[Category: Structural genomic]]
[[Category: Montelione GT]]
[[Category: Ong, M]]
[[Category: Ong M]]
[[Category: Yee, A]]
[[Category: Yee A]]
[[Category: Dna-binding]]
[[Category: Nesg]]
[[Category: Psi-biology]]
[[Category: Sgc]]
[[Category: Transcription regulator]]
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