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==Three-dimensional solution structure of the analogue peptide of omega-conotoxin MVIIC==
==Three-dimensional solution structure of the analogue peptide of omega-conotoxin MVIIC==
<StructureSection load='1v4q' size='340' side='right' caption='[[1v4q]], [[NMR_Ensembles_of_Models | 18 NMR models]]' scene=''>
<StructureSection load='1v4q' size='340' side='right'caption='[[1v4q]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1v4q]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1V4Q FirstGlance]. <br>
<table><tr><td colspan='2'>[[1v4q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_magus Conus magus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V4Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V4Q FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 18 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v4q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1v4q RCSB], [http://www.ebi.ac.uk/pdbsum/1v4q PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v4q OCA], [https://pdbe.org/1v4q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v4q RCSB], [https://www.ebi.ac.uk/pdbsum/1v4q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v4q ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CXO7C_CONMA CXO7C_CONMA]] Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin preferentially blocks P/Q-type calcium channels (Cav2.1/CACNA1A).<ref>PMID:1352986</ref>
[https://www.uniprot.org/uniprot/O17C_CONMA O17C_CONMA] Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin preferentially blocks P/Q-type calcium channels (Cav2.1/CACNA1A) (IC(50)=0.60 nM) (PubMed:10938268, PubMed:1352986). Shows also an inhibition on Cav2.2/CACNA1A channels (IC(50)=7.0 nM) (PubMed:10938268).<ref>PMID:10938268</ref> <ref>PMID:1352986</ref>  
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Kobayashi, K]]
[[Category: Conus magus]]
[[Category: Kohno, T]]
[[Category: Large Structures]]
[[Category: Sasaki, T]]
[[Category: Kobayashi K]]
[[Category: Sato, K]]
[[Category: Kohno T]]
[[Category: Calcium channel blocker]]
[[Category: Sasaki T]]
[[Category: Cystine knot motif]]
[[Category: Sato K]]
[[Category: Omega-conotoxin]]
[[Category: Toxin]]
[[Category: Triple-stranded antiparallel beta-sheet]]
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