4jw3: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| (3 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Selection of specific protein binders for pre-defined targets from an optimized library of artificial helicoidal repeat proteins (alphaRep)== | ==Selection of specific protein binders for pre-defined targets from an optimized library of artificial helicoidal repeat proteins (alphaRep)== | ||
<StructureSection load='4jw3' size='340' side='right' caption='[[4jw3]], [[Resolution|resolution]] 2.60Å' scene=''> | <StructureSection load='4jw3' size='340' side='right'caption='[[4jw3]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4jw3]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4jw3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_malayensis Streptomyces malayensis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JW3 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jw3 OCA], [https://pdbe.org/4jw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jw3 RCSB], [https://www.ebi.ac.uk/pdbsum/4jw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jw3 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/NCZS_STRML NCZS_STRML] NCS has antibiotic activity (for Gram-positive bacteria) and antitumor activity (for certain mouse tumors). NCS binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 17: | Line 17: | ||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4jw3" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Streptomyces malayensis]] | [[Category: Streptomyces malayensis]] | ||
[[Category: Chevrel | [[Category: Synthetic construct]] | ||
[[Category: Desmadril | [[Category: Chevrel A]] | ||
[[Category: Fourati-Kammoun | [[Category: Desmadril M]] | ||
[[Category: Graille | [[Category: Fourati-Kammoun Z]] | ||
[[Category: Guellouz | [[Category: Graille M]] | ||
[[Category: Minard | [[Category: Guellouz A]] | ||
[[Category: Minard P]] | |||
[[Category: Urvoas | [[Category: Urvoas A]] | ||
[[Category: Valerio-Lepiniec | [[Category: Valerio-Lepiniec M]] | ||
[[Category: | [[Category: Van Tilbeurgh H]] | ||
