2fl9: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(15 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:2fl9.gif|left|200px]]


{{Structure
==Evolution of bacteriophage tails: Structure of T4 gene product 10==
|PDB= 2fl9 |SIZE=350|CAPTION= <scene name='initialview01'>2fl9</scene>
<SX load='2fl9' size='340' side='right' viewer='molstar' caption='[[2fl9]], [[Resolution|resolution]] 17.00&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[2fl9]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FL9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FL9 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 17&#8491;</td></tr>
|GENE= 10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= Bacteriophage T4])
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fl9 OCA], [https://pdbe.org/2fl9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fl9 RCSB], [https://www.ebi.ac.uk/pdbsum/2fl9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fl9 ProSAT]</span></td></tr>
}}
</table>
 
== Function ==
'''Evolution of bacteriophage tails: Structure of T4 gene product 10'''
[https://www.uniprot.org/uniprot/BP10_BPT4 BP10_BPT4] Baseplate protein that is part of the baseplate wedge and that connects the short tail fibers to the baseplate (PubMed:16554069). During infection, the baseplate undergoes a conformational change from a dome-shaped to a star-shaped structure. At this point, gp10 rotates and acts as a lever that unfolds the short tail fibers, which then interact with host cell surface receptors. Involved in the tail assembly.<ref>PMID:16554069</ref> <ref>PMID:21129200</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==Overview==
Check<jmol>
The success of tailed bacteriophages to infect cells far exceeds that of most other viruses on account of their specialized tail and associated baseplate structures. The baseplate protein gene product (gp) 10 of bacteriophage T4, whose structure was determined to 1.2 A resolution, was fitted into the cryo-electron microscopy structures of the pre and post-infection conformations of the virus. gp10 functions as a molecular lever that rotates and extends the hinged short tail fibers to facilitate cell attachment. The central folding motif of the gp10 trimer is similar to that of the baseplate protein gp11 and to the receptor-binding domain of the short tail fiber, gp12. The three proteins comprise the periphery of the baseplate and interact with each other. The structural and functional similarities of gp10, gp11, and gp12 and their sequential order in the T4 genome suggest that they evolved separately, subsequent to gene triplication from a common ancestor. Such events are usual in the evolution of complex organelles from a common primordial molecule.
  <jmolCheckbox>
 
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fl/2fl9_consurf.spt"</scriptWhenChecked>
==About this Structure==
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
2FL9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacteriophage_t4 Bacteriophage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FL9 OCA].  
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==Reference==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fl9 ConSurf].
Evolution of bacteriophage tails: Structure of T4 gene product 10., Leiman PG, Shneider MM, Mesyanzhinov VV, Rossmann MG, J Mol Biol. 2006 May 5;358(3):912-21. Epub 2006 Mar 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16554069 16554069]
<div style="clear:both"></div>
[[Category: Bacteriophage t4]]
== References ==
[[Category: Single protein]]
<references/>
[[Category: Leiman, P G.]]
__TOC__
[[Category: Mesyanzhinov, V V.]]
</SX>
[[Category: Rossmann, M G.]]
[[Category: Escherichia virus T4]]
[[Category: Shneider, M M.]]
[[Category: Large Structures]]
[[Category: bacteriophage t4; baseplate; tail; evolution; gp10; structural comparison]]
[[Category: Leiman PG]]
 
[[Category: Mesyanzhinov VV]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:53:44 2008''
[[Category: Rossmann MG]]
[[Category: Shneider MM]]

Latest revision as of 09:24, 14 February 2024

Evolution of bacteriophage tails: Structure of T4 gene product 10

Loading...

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=2fl9&oldid=4058479"