High mobility group protein: Difference between revisions

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New page: <StructureSection load='2gzk' size='340' side='right' caption='Rat HMG1 tandem boxes complexed with DNA (PDB code 2gzk).' scene=''> '''High mobility group protein (HMG)''' is a chroma...
 
Michal Harel (talk | contribs)
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<StructureSection load='2gzk' size='340' side='right' caption='Rat HMGB1 tandem boxes complexed with DNA (PDB code [[2gzk]]).' scene=''>
<StructureSection load='2gzk' size='340' side='right' caption='Rat HMG1 tandem boxes complexed with DNA (PDB code [[2gzk]]).' scene=''>
'''High mobility group protein (HMG)''' is a chromatin protein which organizes the DNA and regulater transcription.  For details see [[HMGI(Y)]].
== Function ==
== Function ==
'''High mobility group protein (HMG)''' is a chromatin protein which organizes the DNA and regulates transcription.  HMG superfamilies differ by their DNA-binding domains.<br />
* '''HMGA'''s bind via an AT-hook domain.  For details on HMGA see [[HMGI(Y)]].<br />
* '''HMGB'''s bind via box domain<ref>PMID:17979838</ref>.<br />
* '''HMGN'''s bind via a nucleosome binding domain.<br /> 


== Disease ==
== Disease ==
Rearrangements of the HMGA2 gene were detected in human benign lipoma tumors<ref>PMID:11576996</ref>.


== Relevance ==
== Relevance ==
Overexpression of HMGB1 is associated with cancer and is targeted for cancer therapy<ref>PMID:20123075</ref>.


== Structural highlights ==
== Structural highlights ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*HMGA
**[[2ezd]], [[2eze]], [[2ezf]], [[2ezg]] – hHMG-1 + DNA - human<br />
*HMGB box 1 domain residues 1-84; tandem boxes domain residues 1-166
**[[2yrq]] – hHMG-1 tandem boxes - human - NMR<br />
**[[2rtu]] – hHMG-1 box 1 - NMR<br />
**[[2ly4]] – hHMG-1 box domain + cellular tumor antigen p53 - NMR<br />
**[[6cij]], [[6cik]], [[6cil]], [[6cim]] – hHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA<br />
**[[6cg0]], [[6oem]], [[6oen]] – hHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA – Cryo EM<br />
**[[8i9m]] – hHMG-1 89-183 + RAGE – Cryo EM<br />
**[[9cg9]] – hHMG-1 + nucleosome – Cryo EM<br />
**[[2eqz]], [[2yqi]] – hHMG-3 box domain - NMR<br />
**[[1j3d]] – pHMG-2 C terminal – pig - NMR<br />
**[[1j3c]] – pHMG-2 C terminal (mutant) - NMR<br />
**[[1j3x]] – pHMG-2 N terminal (mutant) - NMR<br />
**[[1hme]], [[1hmf]] – rHMG-1 B domain – rat - NMR <br />
**[[1aab]] – rHMG-1 A domain - NMR <br />
**[[1ckt]], [[4qr9]] – rHMG-1 A domain + DNA <br />
**[[2gzk]] – rHMG-1 tandem boxes + DNA <br />
**[[5zdz]], [[5ze0]], [[5ze1]], [[5ze2]] – mHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA – mouse<br />
**[[6oeo]], [[6oer]] – mHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA – Cryo EM<br />
**[[1hsm]], [[1hsn]], [[1nhm]], [[1nhn]] – HMG-1 box domain – chinese hamster - NMR <br />
**[[1hma]] – DmHMG-D DNA-binding domain – ''Drosophila melanogaster'' - NMR<br />
**[[1qrv]] – DmHMG-D DNA-binding domain + DNA <br />
**[[3nm9]] – DmHMG-D DNA-binding domain (mutant) + DNA <br />
**[[8r1x]] – DmHMG-D DNA-binding domain + DNA - NMR<br />
*HMG


[[1hme]], [[1hmf]] – rHMG1 B domain – rat - NMR <br />
**[[2mrc]] – HMG residues 17-99 – ''Plasmodium falciparum'' - NMR <br />
[[1aab]] – rHMG1 A domain - NMR <br />
}}
[[1ckt]] – rHMG1 A domain + DNA <br />
[[2gzk]] – rHMG1 tandem boxes + DNA <br />
[[2yrq]] – hHMG1 tandem boxes - human - NMR<br />
[[2rtu]] – hHMG1 box 1 - NMR<br />
[[2ly4]] – hHMG1 box domain + cellular tumor antigen p53 - NMR<br />
[[1hsm]], [[1hsn]], [[1nhm]], [[1nhn]] – HMG1 box domain – chinese hamster - NMR <br />
== References ==
== References ==
<references/>
<references/>


[[Category:Topic Page]]
[[Category:Topic Page]]
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