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==Structure of the central NEAT domain, N2, of the listerial Hbp2 protein, apo form==
==Structure of the central NEAT domain, N2, of the listerial Hbp2 protein, apo form==
<StructureSection load='4nla' size='340' side='right' caption='[[4nla]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='4nla' size='340' side='right'caption='[[4nla]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4nla]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NLA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NLA FirstGlance]. <br>
<table><tr><td colspan='2'>[[4nla]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NLA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NLA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4myp|4myp]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nla OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nla RCSB], [http://www.ebi.ac.uk/pdbsum/4nla PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nla OCA], [https://pdbe.org/4nla PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nla RCSB], [https://www.ebi.ac.uk/pdbsum/4nla PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nla ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HBP2_LISMO HBP2_LISMO] Acts as an extracellular and cell wall-bound hemophore; scavenges host heme and hemoglobin from the environment and also serves as a cell wall receptor for both (Probable). At low hemin (Hn) and hemoglobin (Hb) concentrations adsorbs Hn/Hb and presumably directs it to membrane transporters (Probable). Soluble Hbp2 can probably pass Hn/Hb to cell wall-anchored Hbp2, and both forms can accept Hn/Hb from Hbp1 (PubMed:25315777). May be involved in crossing the digestive barrier in infected animals (PubMed:15661014). Binds host hemin (Probable) (PubMed:21545655, PubMed:25315777). Binds host hemoglobin with affinity in the nanomolar range (PubMed:25315777).<ref>PMID:15661014</ref> <ref>PMID:21545655</ref> <ref>PMID:25315777</ref> <ref>PMID:15661014</ref> <ref>PMID:21545655</ref> <ref>PMID:25315777</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4nla" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Clubb, R T]]
[[Category: Large Structures]]
[[Category: Malmirchegini, G R]]
[[Category: Listeria monocytogenes]]
[[Category: Sawaya, M R]]
[[Category: Clubb RT]]
[[Category: Hbp]]
[[Category: Malmirchegini GR]]
[[Category: Hbp2]]
[[Category: Sawaya MR]]
[[Category: Heme]]
[[Category: Heme binding]]
[[Category: Heme-binding protein]]
[[Category: Hemoglobin]]
[[Category: Listeria]]
[[Category: N2]]
[[Category: Neat domain]]
[[Category: Protein binding]]
Retrieved from "https://proteopedia.org/4nla"