Diguanylate cyclase: Difference between revisions

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<StructureSection load='4urs' size='340' side='right' caption='Diguanylate cyclase GGDEF domain (PDB code [[4urs]]).' scene=''>
<StructureSection load='' size='350' side='right' caption='Diguanylate cyclase GGDEF domain complex with cyclic di-GMP, Mg+2 ion (green) and PEG (PDB code [[3qyy]]).' scene='67/677040/Cv/1'>




== Function ==
== Function ==


'''Diguanylate cyclase''' (DGC) catalyzes the conversion of GTP to cyclic di-GMP and diphosphate. DGC contains the sequence motif GGDEF in its active site.  For more details see [[PleD catalysis]].
'''Diguanylate cyclase''' (DGC) catalyzes the conversion of GTP to [[C-di-GMP]] and diphosphate. <ref>PMID:17697992</ref>  For more details see<br />


== Disease ==
[[C-di-GMP signaling]].


== Relevance ==
== Relevance ==
DGC from ''Borrelia burgdorferi'' is involved in the transmission of spirochetes from ticks to mammals causing Lyme Disease.


== Structural highlights ==
== Structural highlights ==
DGC contains the sequence <scene name='67/677040/Cv/4'>motif GGDEF</scene> in its active site.  <scene name='67/677040/Cv/5'>Cyclic di-GMP and Mg+2 ions interact with two monomers</scene> of DGC.<ref>PMID:22120736</ref>


</StructureSection>
</StructureSection>
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*DGC
*DGC


**[[4urg]], [[4urs]] – TmDGC GGDEF domain – ''Thermotoga maritima''<br />
**[[4urg]], [[6khu]] – TmDGC GGDEF domain 82-248 – ''Thermotoga maritima''<br />
**[[4urq]] – TmDGC GGDEF domain (mutant)<br />
**[[4urq]] – TmDGC GGDEF domain (mutant)<br />
**[[3ign]] – DGC GGDEF domain – ''Marinobacter aquaeolei''<br />
**[[3ign]] – MaDGC GGDEF domain – ''Marinobacter aquaeolei''<br />
**[[4kg1]] – DGC residues 1-150 – ''Xanthomonas campestris''<br />
**[[3h9w]] – MaDGC N terminal<br />
 
**[[8wcn]] – PaDGC + GMPCPP – ''Pseudomonas aeruginosa'' – Cryo EM<br />
*Response regulator PleD
**[[4zmu]] – PaDGC 1-341 <br />
**[[3hvw]], [[4iob]] – DGC GGDEF domain 254-414<br />
**[[7a7e]] – PaDGC GGDEF domain (mutant)<br />
**[[4zmm]] – PaDGC GGDEF domain + C-diGMP<br />
**[[5m3c]] – PaDGC GGDEF domain + GTP<br />
**[[7e6g]] – PaDGC GGDEF domain + SiaC<br />
**[[3n53]] – DGC – ''Pelobacter carbinolicus''<br />
**[[5h5o]] – XcDGC residues 1-150 – ''Xanthomonas campestris''<br />
**[[3qyy]] – XcDGC GGDEF domain + cyclic di-GMP <br />
**[[4urs]] – TmDGC GGDEF domain + cyclic di-GMP<br />
**[[3t9o]] – EcDGC YDEH CZB domain – ''Escherichia coli''<br />
**[[3tvk]], [[4zve]], [[4zvg]], [[4zvh]] – EcDGC YDEH GGDEF domain <br />
**[[4h54]] – EcDGC YDEH (mutant) <br />
**[[4zva]], [[4zvb]] – EcDGC globin domain <br />
**[[4zvc]], [[4zvd]] – EcDGC mid domain <br />
**[[4zvf]] – EcDGC GGDEF domain 297-460 + GTP derivative<br />
**[[6eib]] – DGC GGDEF domain – ''Vibrio cholerae''<br />
**[[6et7]] – IdDGC (mutant) - ''Idiomarina''<br />
**[[5llw]], [[5lly]] – IdDGC + phytochromobilin <br />
**[[5llx]] – IdDGC + phytochromobilin + GTP <br />
**[[6saw]], [[6sax]] – IdDGC chromophore-binding domain 3-312<br />
**[[6hbz]] – DGCB – ''Bdellovibrio bacteriovorus''<br />
**[[6tts]] – CvDGCB GGDEF domain 176-353 + C-diGMP – ''Caulobacter vibrioides'' <br />
**[[6ttr]] – CvDGCB GGDEF+coiled-coil domains 153-353 (mutant) + C-diGMP <br />
**[[7k5n]] – DGC LBD domain 39-286 + Pro – ''Aeromonas caviae''<br />
**[[8px4]] – DGC – ''Leptospira interogans''<br />
**[[8c05]] – DGC + FMN – ''Methylotenera''<br />


**[[1w25]], [[2wb4]] – CvDGC + C-diGMP – ''Caulobacter vibrioides''<br />
**[[2v0n]] – CvDGC + C-diGMP + GTP<br />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]
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