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==The Crystal Structures of holo-wt human Cellular Retinol Binding protein II (hCRBPII) bound to Retinol==
==The Crystal Structures of holo-wt human Cellular Retinol Binding protein II (hCRBPII) bound to Retinol==
<StructureSection load='4qyn' size='340' side='right' caption='[[4qyn]], [[Resolution|resolution]] 1.19&Aring;' scene=''>
<StructureSection load='4qyn' size='340' side='right'caption='[[4qyn]], [[Resolution|resolution]] 1.19&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4qyn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QYN FirstGlance]. <br>
<table><tr><td colspan='2'>[[4qyn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QYN FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=RTL:RETINOL'>RTL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.19&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qyn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qyn RCSB], [http://www.ebi.ac.uk/pdbsum/4qyn PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=RTL:RETINOL'>RTL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qyn OCA], [https://pdbe.org/4qyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qyn RCSB], [https://www.ebi.ac.uk/pdbsum/4qyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qyn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RET2_HUMAN RET2_HUMAN]] Intracellular transport of retinol.  
[https://www.uniprot.org/uniprot/RET2_HUMAN RET2_HUMAN] Intracellular transport of retinol.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Cellular retinol-binding proteins (CRBPs) I and II, which are members of the intracellular lipid-binding protein (iLBP) family, are retinoid chaperones that are responsible for the intracellular transport and delivery of both retinol and retinal. Although structures of retinol-bound CRBPI and CRBPII are known, no structure of a retinal-bound CRBP has been reported. In addition, the retinol-bound human CRBPII (hCRBPII) structure shows partial occupancy of a noncanonical conformation of retinol in the binding pocket. Here, the structure of retinal-bound hCRBPII and the structure of retinol-bound hCRBPII with retinol fully occupying the binding pocket are reported. It is further shown that the retinoid derivative seen in both the zebrafish CRBP and the hCRBPII structures is likely to be the product of flux-dependent and wavelength-dependent X-ray damage during data collection. The structures of retinoid-bound CRBPs are compared and contrasted, and rationales for the differences in binding affinities for retinal and retinol are provided.
 
Structures of holo wild-type human cellular retinol-binding protein II (hCRBPII) bound to retinol and retinal.,Nossoni Z, Assar Z, Yapici I, Nosrati M, Wang W, Berbasova T, Vasileiou C, Borhan B, Geiger J Acta Crystallogr D Biol Crystallogr. 2014 Dec 1;70(Pt 12):3226-32. doi:, 10.1107/S1399004714023839. Epub 2014 Nov 22. PMID:25478840<ref>PMID:25478840</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
==See Also==
</div>
*[[Retinol-binding protein 3D structures|Retinol-binding protein 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Assar, Z]]
[[Category: Homo sapiens]]
[[Category: Berbasova, T]]
[[Category: Large Structures]]
[[Category: Borhan, B]]
[[Category: Assar Z]]
[[Category: Geiger, H]]
[[Category: Berbasova T]]
[[Category: Nosrati, M]]
[[Category: Borhan B]]
[[Category: Nossoni, Z]]
[[Category: Geiger H]]
[[Category: Vasileiou, C]]
[[Category: Nosrati M]]
[[Category: Wang, W]]
[[Category: Nossoni Z]]
[[Category: Yapici, I]]
[[Category: Vasileiou C]]
[[Category: Beta barrel]]
[[Category: Wang W]]
[[Category: Kidney]]
[[Category: Yapici I]]
[[Category: Lover]]
[[Category: Transfer protein]]
[[Category: Transport protein]]
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