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==Crystal Structure of PF10_0123, a GMP Synthetase from Plasmodium Falciparum==
==Crystal Structure of PF10_0123, a GMP Synthetase from Plasmodium Falciparum==
<StructureSection load='3uow' size='340' side='right' caption='[[3uow]], [[Resolution|resolution]] 2.72&Aring;' scene=''>
<StructureSection load='3uow' size='340' side='right'caption='[[3uow]], [[Resolution|resolution]] 2.72&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3uow]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UOW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UOW FirstGlance]. <br>
<table><tr><td colspan='2'>[[3uow]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UOW FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=XMP:XANTHOSINE-5-MONOPHOSPHATE'>XMP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.72&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PF10_0123 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 Plasmodium falciparum])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=XMP:XANTHOSINE-5-MONOPHOSPHATE'>XMP</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/GMP_synthase_(glutamine-hydrolyzing) GMP synthase (glutamine-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.5.2 6.3.5.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uow OCA], [https://pdbe.org/3uow PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uow RCSB], [https://www.ebi.ac.uk/pdbsum/3uow PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uow ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uow OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uow RCSB], [http://www.ebi.ac.uk/pdbsum/3uow PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GUAA_PLAF7 GUAA_PLAF7] Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate, which is the final step of de novo synthesis of GMP (PubMed:17868038, PubMed:21413787, PubMed:26592566, PubMed:32358899). The conversion of XMP to GMP involves the coordinated action of the glutamine amidotransferase (GATase) domain that catalyzes the hydrolysis of the amide side chain of glutamine producing ammonia and the ATP pyrophosphatase (ATPPase) domain that catalyzes the synthesis of adenyl-XMP intermediate from ATP (PubMed:17868038, PubMed:21413787, PubMed:26592566, PubMed:32358899). The ammonia produced by the GATase domain is tunnelled to the ATP-PPase domain where it attacks the adenyl-XMP intermediate generating GMP (PubMed:17868038, PubMed:21413787, PubMed:26592566, PubMed:32358899).<ref>PMID:17868038</ref> <ref>PMID:21413787</ref> <ref>PMID:26592566</ref> <ref>PMID:32358899</ref>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Plasmodium falciparum]]
[[Category: Large Structures]]
[[Category: Amani, M]]
[[Category: Plasmodium falciparum 3D7]]
[[Category: Arrowsmith, C H]]
[[Category: Amani M]]
[[Category: Bountra, C]]
[[Category: Arrowsmith CH]]
[[Category: Dong, A]]
[[Category: Bountra C]]
[[Category: Edwards, A M]]
[[Category: Dong A]]
[[Category: Hills, T]]
[[Category: Edwards AM]]
[[Category: Hui, R]]
[[Category: Hills T]]
[[Category: Lin, Y H]]
[[Category: Hui R]]
[[Category: Loppnau, P]]
[[Category: Lin YH]]
[[Category: Perieteanu, A]]
[[Category: Loppnau P]]
[[Category: Structural genomic]]
[[Category: Perieteanu A]]
[[Category: Weigelt, J]]
[[Category: Weigelt J]]
[[Category: Wernimont, A K]]
[[Category: Wernimont AK]]
[[Category: Ligase]]
[[Category: Purine nucleotide biosynthetic process]]
[[Category: Sgc]]
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