2gmc: Difference between revisions

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[[Image:2gmc.jpg|left|200px]]


{{Structure
==Structure of C12-LF11 bound to the DPC micelles==
|PDB= 2gmc |SIZE=350|CAPTION= <scene name='initialview01'>2gmc</scene>
<StructureSection load='2gmc' size='340' side='right'caption='[[2gmc]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene> and <scene name='pdbligand=DAO:LAURIC ACID'>DAO</scene>
<table><tr><td colspan='2'>[[2gmc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GMC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GMC FirstGlance]. <br>
|ACTIVITY=
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAO:LAURIC+ACID'>DAO</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gmc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gmc OCA], [https://pdbe.org/2gmc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gmc RCSB], [https://www.ebi.ac.uk/pdbsum/2gmc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gmc ProSAT]</span></td></tr>
 
</table>
'''Structure of C12-LF11 bound to the DPC micelles'''
== Function ==
 
[https://www.uniprot.org/uniprot/TRFL_HUMAN TRFL_HUMAN] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.<ref>PMID:12535064</ref> <ref>PMID:22320386</ref>  Lactotransferrin has antimicrobial activity which depends on the extracellular cation concentration.<ref>PMID:12535064</ref> <ref>PMID:22320386</ref>  Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors, while lactoferroxin B and C have somewhat higher degrees of preference for kappa-receptors than for mu-receptors.<ref>PMID:12535064</ref> <ref>PMID:22320386</ref>  The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.<ref>PMID:12535064</ref> <ref>PMID:22320386</ref>  Isoform DeltaLf: transcription factor with antiproliferative properties and inducing cell cycle arrest. Binds to DeltaLf response element found in the SKP1, BAX, DCPS, and SELH promoters.<ref>PMID:12535064</ref> <ref>PMID:22320386</ref>
 
== References ==
==About this Structure==
<references/>
2GMC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GMC OCA].  
__TOC__
 
</StructureSection>
==Reference==
[[Category: Large Structures]]
The acyl group as the central element of the structural organization of antimicrobial lipopeptide., Japelj B, Zorko M, Majerle A, Pristovsek P, Sanchez-Gomez S, Martinez de Tejada G, Moriyon I, Blondelle SE, Brandenburg K, Andra J, Lohner K, Jerala R, J Am Chem Soc. 2007 Feb 7;129(5):1022-3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17263370 17263370]
[[Category: Synthetic construct]]
[[Category: Protein complex]]
[[Category: Japelj B]]
[[Category: Japelj, B.]]
[[Category: DAO]]
[[Category: NH2]]
[[Category: helix]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:06:24 2008''
Retrieved from "https://proteopedia.org/2gmc"