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==Bromoderivative-2 of amyloid-related segment of alphaB-crystallin residues 90-100==
==Bromoderivative-2 of amyloid-related segment of alphaB-crystallin residues 90-100==
<StructureSection load='3sgm' size='340' side='right' caption='[[3sgm]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='3sgm' size='340' side='right'caption='[[3sgm]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3sgm]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SGM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SGM FirstGlance]. <br>
<table><tr><td colspan='2'>[[3sgm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SGM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SGM FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7006&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=A8E:(2S)-2-AMINO-4-BROMOPENT-4-ENOIC+ACID'>A8E</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A8E:(2S)-2-AMINO-4-BROMOPENT-4-ENOIC+ACID'>A8E</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3sgn|3sgn]], [[3sgo|3sgo]], [[3sgp|3sgp]], [[3sgr|3sgr]], [[3sgs|3sgs]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sgm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sgm OCA], [https://pdbe.org/3sgm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sgm RCSB], [https://www.ebi.ac.uk/pdbsum/3sgm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sgm ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sgm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sgm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sgm RCSB], [http://www.ebi.ac.uk/pdbsum/3sgm PDBsum]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN]] Posterior polar cataract;Alpha-crystallinopathy;Zonular cataract;Familial isolated dilated cardiomyopathy;Fatal infantile hypertonic myofibrillar myopathy. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN] Posterior polar cataract;Alpha-crystallinopathy;Zonular cataract;Familial isolated dilated cardiomyopathy;Fatal infantile hypertonic myofibrillar myopathy. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN]] May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.  
[https://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN] May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3sgm" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cascio, D]]
[[Category: Homo sapiens]]
[[Category: Eisenberg, D]]
[[Category: Large Structures]]
[[Category: Laganowsky, A]]
[[Category: Cascio D]]
[[Category: Sawaya, M R]]
[[Category: Eisenberg D]]
[[Category: Amyloid]]
[[Category: Laganowsky A]]
[[Category: Amyloid oligomer]]
[[Category: Sawaya MR]]
[[Category: Beta cylindrin]]
[[Category: Protein fibril]]
Retrieved from "https://proteopedia.org/3sgm"