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==A new class of suicide inhibitor blocks nucleotide binding to pyruvate kinase==
==A new class of suicide inhibitor blocks nucleotide binding to pyruvate kinase==
<StructureSection load='3srk' size='340' side='right' caption='[[3srk]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
<StructureSection load='3srk' size='340' side='right'caption='[[3srk]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3srk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_mexicana Leishmania mexicana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SRK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SRK FirstGlance]. <br>
<table><tr><td colspan='2'>[[3srk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_mexicana Leishmania mexicana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SRK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SRK FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=LSA:1,2-BENZISOTHIAZOL-3(2H)-ONE+1,1-DIOXIDE'>LSA</scene>, <scene name='pdbligand=PTK:PYRENE-1,3,6,8-TETRASULFONIC+ACID'>PTK</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1pkl|1pkl]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=LSA:1,2-BENZISOTHIAZOL-3(2H)-ONE+1,1-DIOXIDE'>LSA</scene>, <scene name='pdbligand=PTK:PYRENE-1,3,6,8-TETRASULFONIC+ACID'>PTK</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PYK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5665 Leishmania mexicana])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3srk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3srk OCA], [https://pdbe.org/3srk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3srk RCSB], [https://www.ebi.ac.uk/pdbsum/3srk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3srk ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyruvate_kinase Pyruvate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.40 2.7.1.40] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3srk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3srk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3srk RCSB], [http://www.ebi.ac.uk/pdbsum/3srk PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KPYK_LEIME KPYK_LEIME]


==See Also==
==See Also==
*[[Pyruvate Kinase|Pyruvate Kinase]]
*[[Pyruvate kinase 3D structures|Pyruvate kinase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Leishmania mexicana]]
[[Category: Leishmania mexicana]]
[[Category: Pyruvate kinase]]
[[Category: Auld DS]]
[[Category: Auld, D S]]
[[Category: Blackburn EA]]
[[Category: Blackburn, E A]]
[[Category: Boxer M]]
[[Category: Boxer, M]]
[[Category: Fothergill-Gilmore LA]]
[[Category: Fothergill-Gilmore, L A]]
[[Category: McNae IW]]
[[Category: McNae, I W]]
[[Category: Michels PAM]]
[[Category: Michels, P A.M]]
[[Category: Morgan HP]]
[[Category: Morgan, H P]]
[[Category: Shen M]]
[[Category: Shen, M]]
[[Category: Walkinshaw MD]]
[[Category: Walkinshaw, M D]]
[[Category: Walsh M]]
[[Category: Walsh, M]]
[[Category: Wear MA]]
[[Category: Wear, M A]]
[[Category: Phosphenolpyruvate]]
[[Category: Phospho transfer]]
[[Category: Sugar kinase]]
[[Category: Tim barrel]]
[[Category: Transferase-inhibitor complex]]
Retrieved from "https://proteopedia.org/3srk"