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==2.2 Angstrom Crystal Structure of Cytidine deaminase from Vibrio cholerae in Complex with Zinc and Uridine==
==2.2 Angstrom Crystal Structure of Cytidine deaminase from Vibrio cholerae in Complex with Zinc and Uridine==
<StructureSection load='4eg2' size='340' side='right' caption='[[4eg2]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='4eg2' size='340' side='right'caption='[[4eg2]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4eg2]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EG2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EG2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4eg2]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EG2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EG2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=URI:URIDINE'>URI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=URI:URIDINE'>URI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cdd, VC_1231 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=666 Vibrio cholerae])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eg2 OCA], [https://pdbe.org/4eg2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eg2 RCSB], [https://www.ebi.ac.uk/pdbsum/4eg2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eg2 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cytidine_deaminase Cytidine deaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.4.5 3.5.4.5] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eg2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4eg2 RCSB], [http://www.ebi.ac.uk/pdbsum/4eg2 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CDD_VIBCH CDD_VIBCH] This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.[HAMAP-Rule:MF_01558]


==See Also==
==See Also==
*[[Deaminase|Deaminase]]
*[[Deaminase 3D structures|Deaminase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cytidine deaminase]]
[[Category: Large Structures]]
[[Category: Vibrio cholerae]]
[[Category: Vibrio cholerae]]
[[Category: Anderson, W F]]
[[Category: Anderson WF]]
[[Category: Structural genomic]]
[[Category: Grimshaw S]]
[[Category: Grimshaw, S]]
[[Category: Minasov G]]
[[Category: Minasov, G]]
[[Category: Papazisi L]]
[[Category: Papazisi, L]]
[[Category: Savchenko A]]
[[Category: Savchenko, A]]
[[Category: Skarina T]]
[[Category: Skarina, T]]
[[Category: Wang Y]]
[[Category: Wang, Y]]
[[Category: Wawrzak Z]]
[[Category: Wawrzak, Z]]
[[Category: Hydrolase]]
[[Category: Ump synthesis]]
[[Category: Zn binding]]

Latest revision as of 08:21, 6 December 2023

2.2 Angstrom Crystal Structure of Cytidine deaminase from Vibrio cholerae in Complex with Zinc and Uridine

4eg2, resolution 2.20Å

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