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==Structure of OSH4 with a cholesterol analog==
==Structure of OSH4 with a cholesterol analog==
<StructureSection load='4f4b' size='340' side='right' caption='[[4f4b]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
<StructureSection load='4f4b' size='340' side='right'caption='[[4f4b]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4f4b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F4B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F4B FirstGlance]. <br>
<table><tr><td colspan='2'>[[4f4b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F4B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F4B FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=L39:(3BETA,9BETA,25R)-3-HYDROXY-26-IODOCHOLEST-5-ENE-16,22-DIONE'>L39</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.87&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zhy|1zhy]], [[1zhx|1zhx]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=L39:(3BETA,9BETA,25R)-3-HYDROXY-26-IODOCHOLEST-5-ENE-16,22-DIONE'>L39</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KES1, OSH4, YPL145C, LPI3C, P2614 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Saccharomyces cerevisiae S288c])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f4b OCA], [https://pdbe.org/4f4b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f4b RCSB], [https://www.ebi.ac.uk/pdbsum/4f4b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f4b ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f4b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4f4b RCSB], [http://www.ebi.ac.uk/pdbsum/4f4b PDBsum]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/KES1_YEAST KES1_YEAST] Plays a role in ergosterol synthesis.
We have synthesized 16,22-diketocholesterol, a novel ligand for oxysterol-binding protein Osh4, and determined X-ray structure of the diketocholesterol in complex with Osh4. The X-ray structure shows that alpha7 helix of Osh4 assumes open conformation while the rest of Osh4, closed conformation, implying this diketocholesterol-bound Osh4 structure may represent a structural intermediate between the two conformations.
 
Synthesis and structure of 16,22-diketocholesterol bound to oxysterol-binding protein Osh4.,Koag MC, Cheun Y, Kou Y, Ouzon-Shubeita H, Min K, Monzingo AF, Lee S Steroids. 2013 Jun 10;78(9):938-944. doi: 10.1016/j.steroids.2013.05.016. PMID:23756172<ref>PMID:23756172</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
==See Also==
</div>
*[[Oxysterol-binding protein homolog|Oxysterol-binding protein homolog]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Saccharomyces cerevisiae s288c]]
[[Category: Large Structures]]
[[Category: Cheun, Y]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Koag, M C]]
[[Category: Cheun Y]]
[[Category: Lee, S]]
[[Category: Koag MC]]
[[Category: Monzingo, A F]]
[[Category: Lee S]]
[[Category: Lipid binding protein]]
[[Category: Monzingo AF]]
[[Category: Oxysterol]]
[[Category: Sterol binding protein]]
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